Sealed Envelope provide high quality and easy to use online software applications for randomising patients into clinical trials and recording their case report form data (EDC and ePRO).
Proven, reliable, centralised randomisation services to suit every type of randomised clinical trial (RCT). Tell us about your clinical trial and we can set up a randomisation or code break system to meet your requirements. With over 15 years of experience, and a range of automated systems for randomisation by internet or text message, you can trust Sealed Envelope with your trial.
We have two options for randomisation comprehensive and simple.
Use our comprehensive randomisation service to randomise patients online. Code breaking can also be performed by authorised users. Learn more
A qualified statistician will oversee the creation of your system. We can give you advice if required on the options available to suit your trial.
Each system is tailored to fit your trial so you only get the features you need. This makes the system easier to use by hiding unnecessary complexity.
Users with administrator accounts can view all randomisations as well as reports showing randomisations by site, investigator and over time.
We also offer a simple randomisation service intended for non-commercial clinical trials that do not require minimisation. Get started!
You set-up the system yourself online. It only takes a few minutes and you can be randomising immediately!
The first 50 randomisations for simple systems are free. Optional features such as stratification, named treatment groups and unequal allocation can be activated for a low fee.
An option to allow randomisation by sending a text message can be added to your simple system. This is useful for users in the field who may not have good internet access.
Red Pill is Sealed Envelope's online database application for electronic data capture (EDC) and ePRO - recording case report form data for patients participating in clinical trials. Investigators and subjects enter forms directly online, and trial managers can manage the data in real time. Learn more
Contact us if you would like a demonstration of our comprehensive randomisation service or Red Pill, have any specific queries about our services or would like a quote for your clinical trial.
Thank you very much, and also let me iterate what we put into our acknowledgement: Thank you for your randomization service which was excellent, particularly given the mid-trial amendments to our treatment.
Thees Spreckelsen, DPhil, Department of Social Policy and Intervention, University of OxfordI have recommended Sealed Envelope to many of my colleagues because it is always reliable, efficient and helpful.
Belinda Lees Assistant Director, Royal Brompton Clinical Trials and Evaluation UnitFantastic good technical and academic support.
Professor Phillipa HayPersonal service & help always at the end of an email. The system is very easy to use. You are willing to work with the customer to adapt the system to suit the requirements of the trial at the start and make any further changes as necessary during the course of the trial.
Sian Wells, former Trial Manager at Bristol CTEUVery simple system, easy to use and backup support has been excellent. Team are always understanding and easy to talk too.
Diane Picton, Clinical Trial Monitor and co-ordinatorReliable and easy to use.
Chris Rogers, Co-director Bristol CTEUEasy and straightforward to use. I was able to set up my own randomisation account when I was designing a clinical trial for my dissertation.
Zoe Beardow, Critical Care Research SisterLogging on is always quick and easy. The system is never down. The system is functional in its logic. The randomisation was very easy to set up and use.
Kate Levett, PhD student, UWS AustraliaGood service, easy to use website - help available when needed.
Dr Barbara Sheil, Clinical Project Manager, Telethon Institute for Child Health Research, Perth, Western AustraliaI think the functions and set-up processes to add new users/centres are easy to use and intuitive.
Margo Childs, TANDEM Trial ManagerThank you for your help with this study. The service has been fantastic and reliable and I would be very happy to use it again in the future.
Sharon Hulme, Research Manager, Vascular & Stroke Centre, University of ManchesterNever seen a downtime, good customer service, technically good and requests for changes/updates are handled really well.
Mithun Sortur, Senior Clinical Data Manager, University of OxfordThe service is very easy to set up and use and is a very affordable solution.
Melissa Dobson, Operations DirectorClear, easy to use - no complicated instructions. Our statisticians like it.
Professor Janet Powell, Imperial CollegeUser friendly databases, very intuitive and also flexible in terms of design.
Monica Yanez-Lopez, Data managerQuick, easy and friendly
Lourdes Ibáñez, MD. Professor of Pediatrics, University of BarcelonaI would absolutely recommend Sealed Envelope to colleagues: The ability to link in the randomisation facility for our clinical trial to the database; The ease of use of the CRF builder, relatively easy to understand and easy to get up to speed with all functions available. Support is readily available when required.
Mr Neil Nathwani, Research OptometristEasy and fast to use.
Doctor GribelGreat product, great service. I've already recommended to over a dozen colleagues.
Gus Gazzard, Chief Investigator LiGHT Trial and Consultant Ophthalmic SurgeonHelpful personal service, simple website
Caroline Coats, British Heart Foundation Research FellowEasy to use, the randomisation and eCRFs are simple and straightforward, training others to use these can be done remotely.
Steven Robertson, Senior Data Manager, Clinical Trials Unit at LSHTM.The system we have set up is easy to use and it does exactly what it says on the tin.
Stella Silvester, Trial Co-ordinator, University of CambridgeSystem is fully bespoke which is very useful for our department as each trial is different! Excellent and efficient communication with developers.
Daphne Babalis, Trial Manager CTEUEase of set up and very easy to use/access.
Emma Hedley, Senior Clinical Trials ManagerSealed Envelope have provided us with an efficient service in setting up an online screening, randomisation and data collection service for our clinical trial (ECST-2). This has involved several iterations of the development process and they have been patient and helpful at each stage.
Roland L Featherstone, Trial Manager, The 2nd European Carotid Surgery Trial (ECST-2)Efficient and straightforward service, runs perfectly.
Ona McCarthy, Research and Trial CoordinatorI love it.
Dan Horner, Research fellow, Emergency Medicine / Critical care, University of Manchester / Central Manchester University Hospitals NHS Foundation Trust
Join our mailing list to keep up to date with Sealed Envelope news and product updates.
Sealed Envelope is certified as meeting the standards ISO/IEC 27001 information security management, Cyber Essentials, and NHS England Data Security and Protection Toolkit. We are registered with the UK Information Commissioner's Office and comply with UK/EU GDPR. Read more about security and data protection…
