Trials

Prognostic models

This is a list of trials which are using or have used Red Pill or our comprehensive randomisation service. Hundreds more trials have also been set-up on our popular simple randomisation service.

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2.4 Study

Compliance with a high energy content, low volume Oral Nutritional Supplement (ONS)

2022.03: Robotics and JII UK RCT

A Prospective, Single-blind, Multi-Centre, Randomised Controlled Study to Evaluate the Clinical and Patient Reported Outcomes Following Unicompartmental Knee Arthroplasty with a Robotic Assisted Technique

3DPiPPIn 2

The clinical impact of customised Positive Airway Pressure (PAP) therapy interfaces vs usual care in the treatment of patients with sleep disordered breathing

3Rs

A randomised controlled trial to investigate the effect of structured education on people at high risk of cardiovascular disease" where name like '3R (Ready to Reduce Risk) study

4PICU

A prospective randomised controlled study of a directed psycho-educational tool to prevent psychological sequelae following Paediatric Intensive Care admission

65 Trial

Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension

ABBA

Published

Acetic Acid guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomised tandem endoscopy trial. The ABBA study

ABC-19

To determine whether administration of almitrine bismesylate can ameliorate hypoxaemia in Covid-19 and augment effectiveness of supplementary oxygen therapy and respiratory support

ABRA

The use of Benralizumab, an interleukin-5 receptor-α monoclonal antibody as treatment of acute exacerbations of airways disease

ACE-CF

AceFIT

Acetabular Fractures in older patients Intervention Trial. A feasibility study comparing three methods of treatment of acetabular fractures in older patients; surgical fixation versus surgical fixation and hip replacement versus non-surgical treatment

ACER

Assessing the Clinical and cost-Effectiveness of inpatient mental health Rehabilitation services provided by the NHS and independent sector (ACER)

ACUMISS

Published

Acupuncture treatment with threatened miscarriage: an exploratory study. Trial being conducted by the Centre for Complementary Medicine Research, University of Western Sydney.

ADAPT

A novel targeted treatment for reducing anxiety in joint hypermobility: a proof of concept study (ADAPT)

ADEPT-2

A multicentre randomised controlled trial of guided self-help versus treatment as usual for depression for autistic adults

ADepT-PD

Antidepressants Trial in Parkinson's Disease (ADepT-PD)

ADIMQIS-2018-01

A PHASE III Study of Immunogenicity and Safety Evaluation of AdimFlu-S (QIS)

AFCRO-090

Efficacy and tolerability of NL-01, a food ingredient, in older adults at risk of Acute Respiratory Tract Infections (ARTI) during the winter season

AFCRO-130

Effect of colon delivered vitamin C on gut microbiota and related health biomarkers in healthy older adults

AFCRO-131

Effect of colon delivered vitamin B2 and of a vitamin mix on gut microbiota and related health biomarkers in healthy older adults.

AFTER

Aggression Following Traumatic Brain Injury (TBI): Effectiveness of Risperidone – a Feasibility RCT

AIAT001

AmnioFix for Achilles Tendonitis, Phase III IND

AIMS

Published

A prospective, randomised, placebo-controlled double blind, multi-centre study of the effects of Irbesartan on aortic dilatation in Marfan syndrome.

AIOA001

AmnioFix Injectable in the Treatment of Knee Osteoarthritis, Phase 2B

AIPF007

AmnioFix for Plantar Fasciitis, Phase III IND

AIRS

Published

Auto-inflation in children with otitis media with effusion (AIRS). A multi-centre trial being run by the Primary Care Clinical Trials Unit at the University of Oxford.

ALERT

Attention Training for Learning Enhancement and Resilience Trial

AMIHOT III

SSO2 Therapy: AMIHOT III study

Anterior Gen Plus

A Prospective, Single Center, Randomized, Intra-Patient Controlled Study Evaluating OsteoStrandTM Plus Demineralized Bone Fibers versus ViviGen® Lumbar Interbody Fusion

ANTLER

ANTidepressants to prevent reLapse in dEpRession

APACS (HPR) Trial

Published

Evaluating the benefit of Additional Platelet inhibition in Acute Coronary Syndrome patients with high platelet reactivity undergoing PCI. A Randomised comparison of prasugrel versus clopidogrel re-loading in patients with ACS undergoing urgent PCI with persistent high platelet reactivity.

Apnoea

Obstructive sleep apnoea and retinal vasculature reactivity

APPLE-Tree

Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: Pilot of the intervention and Randomised Controlled Trial

ARISE

Respiratory support with standard low flow oxygen therapy, frugal continuous positive airway pressure, or high-flow oxygen therapy in adults with acute hypoxemic respiratory failure in Uganda. Protocol for a randomized, open label, clinical trial.

Aristacat

A randomised phase II study to seek evidence that the addition of a potent src-inhibitor, AZD0530, to conventional aromatase inhibition, delays the onset of endocrine resistance in post- menopausal women with advanced breast cancer.

ARREST

A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out-of-hospital cardiac arrest (ARREST)

ASEPTIC

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis (ASEPTIC)

ASK

The ASK trial: a feasibility trial of strategies to improve AccesS to Kidney transplantation

ASPRE

Combined multi-marker screening and randomised patient treatment with aspirin for evidence-based pre-eclampsia prevention.

ASPRE-T

Aspirin versus placebo in twin pregnancies for preeclampsia prevention: A multicenter, randomised, double-blind, placebo-controlled trial (ASPRE-T)

ASSERT

The ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) Randomised Controlled, Feasibility in Older People) Trial

ATHENA

Amitriptyline for the prevention of post-herpetic neuralgia

ATP

A randomised, placebo-controlled, double-blind trial of the antidepressant efficacy of a novel CNS-penetrant P2X7 receptor antagonist, JNJ-54175446, in people with major depressive disorder, an incomplete response to monoaminergic antidepressant drugs, and a biomarker profile predictive of active P2X7 signalling

AttackMS

Natalizumab for the treatment of people with inflammatory demyelination suggestive of multiple sclerosis, or definite multiple sclerosis, at first presentation.

ATTIRE

Albumin To prevenT Infection in chronic liveR failurE

AutismCHIME

Child Improvisational Music Therapy Effectiveness Randomised Controlled Trial for autistic children aged 7 – 11 [Autism-CHIME]

Autodecra2

AZA-PD

Azathioprine Immunosuppression and Disease Modification in Parkinson’s Disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial

B-PHIT

Published

Use of Endothelin-1 antagonists in patients with established pulmonary hypertension and fibrotic lung disease - a randomised, placebo controlled, double-blinded study.

BACHb

Breathing Assistance in CHildren with bronchiolitis

BALANCE

Phase 2a two-site randomised controlled trial to determine safety of and adherence with a new ‘Binocularly Balanced Viewing’ treatment for unilateral amblyopia compared with standard treatment in children age 3-8 years

BARI-OPTIMISE

A double-blinded, randomised, placebo-controlled trial of liraglutide 3.0 mg in patients with poor weight-loss and a suboptimal glucagon-like peptide-1 response following bariatric surgery.

BARI-STEP

A double-blinded, randomised, placebo- controlled trial of semaglutide 2.4 mg in patients with poor weight-loss following bariatric surgery

BASIC

Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury

BASIC2

A randomized, controlled trial of the use of a dedicated ballooned intercostal drain

BCIS-1

Published

Ballon-pump Coronary Intervention Study.

BEARS

BEARS - Both EARS training package (BEARS) to maximise hearing abilities in older children and teenagers with bilateral cochlear implants

BEAT LUPUS

Published

Safety and efficacy of Belimumab After B cell depleTion therapy in systemic LUPUS erythematosus

BEAT-SA (T2-HIGH)

Beyond Allergic Th2 Severe Asthma (BEAT-SA)

BEAT-SA (T2-LOW)

Beyond Allergic Th2 Severe Asthma (BEAT-SA)

BEET-BP

The effects of dietary nitrate supplementation on pregnancies complicated by chronic and new onset hypertension

Betashot

A feasibility study of the use of Betashot, a medium chain triglyceride-based (MCT) food for special medical purposes (FSMP) in children and adults with epilepsy.

BH-HF3.0

Effect of BH-HF3.0 on Vasomotor Symptoms (VMS) in Menopausal Women: A De-Centralized, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

BHF PROTECT-TAVI

British Heart Foundation Randomised Trial of Routine Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation

BHiRCH

Published

Pilot cluster randomised trial of an evidence based intervention to reduce avoidable hospital admissions in residents in care homes (the Better Health in Residents in Care Homes study)

BIC-T&T

Efficacy of BIC/F/TAF versus standard of care in the treatment of new HIV infection diagnoses in the context of ‘test and treat’

BID - ID Database

A pilot randomised controlled trial of one to one befriending by volunteers, compared to Usual Care, in reducing symptoms of depression in people with intellectual disability (ID)

BIOVAS

Biologics in refractory vasculitis (BIOVAS): A pragmatic, randomised, double-blind, placebo-controlled, modified-crossover trial of biologic therapy for refractory primary non-ANCA associated vasculitis in adults and children

BLIPA – Bacterial Lysate in Preventing Asthma

Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis: a randomised placebo-controlled trial

BOND

The Benefit Of Night splinting in Dupuytrens

BPPV in TBI Feasibility study

A feasibility investigating different interventions for the treatment of benign paroxysmal positional vertigo in acute traumatic brain injury patients

BRAVE

BRAVE Trial. Broad-spectrum Cognitive Remediation Available to Veterans: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury (mTBI). Posit Science.

Breathemor-HF

Morphine for the relief of breathlessness in heart failure.

Bride

BRIDE (Barrett's Randomised Intervention for Dysplasia by Endoscopy) - a feasibility study

Brightmind

Randomised double-blind controlled trial of connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant moderate to severe depression: evaluation of efficacy, cost effectiveness and mechanism of action

BT-LIFE

BT-LIFE, Brain Tumours, Lifestyle Interventions and Fatigue

By-Band-Sleeve

Gastric BYpass or adjustable gastric BANDing surgery or Sleeve Gastrectomy surgery to treat morbid obesity: a multi-centre randomised controlled trial.

CALM-COVID Trial

Alpha-1 Adrenergic Receptor Antagonism to Prevent Cytokine Storm Syndrome and Severe COVID-19: A Pragmatic Randomized Double-Blind Phase 2 Study Comparing the Efficacy of Doxazosin vs. Placebo for SARS-CoV-2 infection.

Calories

Published

A phase III, open, randomised, multi-site trial to assess the clinical and cost-effectiveness of early parenteral, compared with early enteral, nutritional support in critically ill patients.

CamBMT1

Cambridge Brain Mets Trial 1

CAMELOT

Can Do Ramadan

A Randomised Controlled Trial for People with Established Type 2 Diabetes during Ramadan: Canagliflozin (Invokana™) vs. standard dual therapy regimen.

canACT

The feasibility of recruiting and undertaking a randomised controlled trial to help with coping using two talking interventions, ACT or a Talking Control for people receiving treatment to control their cancer symptoms.

Cannabidiol

A phase IIa/b, randomised, double-blind, placebo-controlled, single-site, parallel group clinical trial to examine cannabidiol (CBD) as a pharmacological treatment for cannabis dependence in a young cannabis dependent population.

CanTalk

CanTalk: the clinical and cost effectiveness of CBT plus treatment as usual for the treatment of depression in advanced cancer; a randomised controlled trial.

CAP-IT

Published

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): A randomised controlled trial

Capture2

Cardia

Published

The Coronary Artery Revascularisation in Diabetes (CARDia) trial

CARMS

A psychological intervention for suicide applied to patients with psychosis: The CARMS trial (Cognitive Approaches to Combatting Suicidality).

CAVIAR

A Prospective, Randomised Controlled Trial Comparing Glycaemic Benefits of Active Versus Passive Lifestyle Intervention in Kidney Allograft Recipients.

CCAP-RCT

Efficacy and safety of novel treatment options for adults with COVID-19 pneumonia. A double-blinded, randomized, multi-stage, 6-armed placebo-controlled trial in the framework of an adaptive trial platform

CCMR Two

CCMR Two: A phase IIa, randomised, double-blind, placebo-controlled trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing- remitting multiple sclerosis already on disease-modifying therapy

CHAMP UK

Low-dose atropine eye drops to reduce progression of myopia in children: a multi- centre placebo controlled randomised trial in the United Kingdom, (CHAMP UK)

CHANTS

ChariotMS

A national (UK), multi-centre, randomised, double-blind, placebo-controlled (1:1) phase IIb efficacy trial with cost-utility analysis of oral cladribine (3.5mg/kg over two years) in people with advanced multiple sclerosis (EDSS 6.5-8.5).

CHART-1

Congestive Heart failure Cardiopoietic Regenerative Therapy (CHART-1) trial. Efficacy and Safety of Bone Marrow-Derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the treatment of chronic advanced ischemic Heart Failure. Cardio3 BioSciences SA.

CHIEF-PD

Cholinesterase inhibitors to prevent falls in Parkinson’s Disease: A multicentre, phase III, double blind, randomised control trial of the cholinesterase inhibitor, rivastigmine versus placebo to prevent falls in Parkinson’s disease

CHIKA01

A single-centre, double-blind, double-dummy placebo controlled, randomized Phase Ib Study to Evaluate the Safety and Immunogenicity of the Candidate Chikungunya vaccine ChAdOx1 Chik and the Zika vaccine ChAdOx1 Zika in Healthy Adults in Mexico, given as Standalone Vaccines or Co-administered

CHIP-BCIS3

Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading (CHIP-BCIS3)

Chocolate Touch IDE Study

A Randomized Trial to confirm the Safety and Effectiveness of Chocolate Touch™ Paclitaxel Coated PTA Balloon Catheter, in Above the Knee Lesions

CIRCLE

Randomised controlled trial of the clinical and cost-effectiveness of a contingency management intervention for reduction of cannabis use and of relapse in early psychosis.

CirrhoCare

CL-0001

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

CLEAR

A 2x2 factorial randomised examiner blind open label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in bronchiectasis

COBALT

COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial

Colo-prevent MAIN

A phase 2/3 randomised platform trial assessing the efficacy of aspirin, aspirin plus metformin, or resveratrol, for colorectal polyp prevention in patients undergoing surveillance in the Bowel Cancer Screening Programme

COMBIVAS

A randomised, double blind, controlled mechanistic study of rituximab and belimumab combination therapy in PR3 ANCA-associated vasculitis

COMBO

COMET

Cooling in Mild Encephalopathy Trial (COMET) – Feasibility study

CoMICS

Conventional versus Minimally Invasive extra-corporeal circulation in patients undergoing Cardiac Surgery: a randomised controlled trial

CoMiTED

Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED): A Randomised Controlled Trial

COMMITS

Confirming the Mechanism of Motivational Interviewing Therapy after Stroke: a multi-centre randomised controlled trial

Community Navigator

Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistant depression in secondary mental health services

Compare

Cognitive behavioural therapy or medication for psychosis - a randomised evaluation.

COMPULSE

Comparison trial of open-tip pulsed needle biopsy and conventional core biopsy in axillary lymph nodes (COMPULSE)

CONCEPT

A randomised phase II pilot study of 3 weekly Cabazitaxel versus weekly Paclitaxel chemotherapy in the first line treatment of HER2 negative breast cancer.

CONFORM-OH

Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: A Randomised Controlled Trial

CONRAD MATRIX-001

CONSEPT

Contraceptive Choices

Published

Increasing uptake and adherence to long-acting reversible contraceptive (LARC) methods in young women

CONTROL

The effect of canagliflozin 300mg in subjects without diabetes after bariatric surgery on glucose homeostatis (the CONTROL study). A proof of concept, randomised, open label, two period cross over study

CONVINCE

COlchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke – a randomised clinical trial of low-dose colchicine for secondary prevention after stroke

COOL AMI - InCor

Hypothermia as an adjunctive therapy to percutaneous coronary intervention in patients with acute myocardial infarction.

COOL AMI EU Pilot Trial

Published

A Multicenter, Prospective, Randomized Controlled Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction

COOL AMI EU Pivotal

Multicenter, prospective, randomized-controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction

COPD

Innovative use of antibiotics in the prevention of exacerbations of chronic obstructive pulmonary disease (COPD).

COPD Rehab

Reducing perioperative risk in chronic obstructive pulmonary disease with pre-operative pulmonary rehabilitation

COPD-HELP

A Randomised Controlled Trial of Mepolizumab Initiated During Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD

COPD-ST2OP

A randomised placebo-controlled trial of anti-ST2 in COPD (COPDST₂OP)

COPS

Colchicine in Patients with Acute Coronary Syndromes

CorCal

Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events

CORE Phase 3

CORE Phase 3. A randomised controlled trial of a peer-provided self-management intervention for people leaving CRT care.

CORE Pilot

CORI.2019.06

A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in unicondylar knee arthroplasty (UKA) procedures

CORI.2020.08

A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in total knee arthroplasty (TKA) procedure

COSAK

Published

A randomised phase II study evaluating cediranib vs. cediranib and saracatanib in patients with relapsed metastatic clear cell renal cancer.

COVIPLEX

A Randomised Controlled Trial of plasma exchange with standard of care compared to standard of care alone in the treatment of severe COVID- 19 infection

Crash 3

Published

Tranexamic acid for the treatment of significant traumatic brain injury: an international randomised, double blind placebo controlled trial

CROMIS 2

Published

Microbleeds and genetic risk factors to predict the risk of intracranial haemorrhage in patients treated with anticoagulation following cardioembolic stroke due to atrial fibrillation.

Crown Coronation

CROWN CORONATION (COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION) is an innovative prophylaxis clinical trial in response to COVID-19. The trial will assess candidate interventions that either modify the host immune response or target SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) to prevent symptomatic COVID-19. CROWN CORONATION is designed as a platform trial, such that interventions or combinations of interventions can be added as arms to which participants will be randomised.

CT CROP

Randomised controlled trial comparing the diagnostic yield of Radial Endo-Bronchial Ultra-Sound (R-EBUS) guided Cryo-biopsy Vs. CT guided transthoracic biopsy in patients with parenchymal lung lesion.

CUPPA

Comprehensive moUthcare to Prevent Postoperative pneumoniA

CVLPRIT

Published

Complete Versus Lesion-only PRimary PCI PiloT Study. Prospective observational registry and open multi-centre randomised controlled trial (RCT) in a subset of patients with multi-vessel coronary artery disease.

DANCE Pilot Study

Direct Angioplasty for Non ST-Elevation Acute Coronary Events (DANCE Pilot Study). The aim of the DANCE pilot study is to compare an immediate versus delayed revascularisation strategy in high risk patients with non ST elevation Myocardial Infarction (NSTEMI).

DARC

A Phase I, Storer Design, open-label, cross-sectional, single site trial of ANX776 in healthy volunteers, progressive glaucoma/glaucoma-suspect/ocular hypertensive subjects and non-arteritic anterior ischaemic optic neuropathy subjects.

DARC II

A phase II, open label, non-randomised, single centre, clinical trial of ANX776 in healthy volunteers and patients with Glaucoma, Age-Related Macular Degeneration and Optic Neuritis

DART

Flow modulation using a surface modified device in the treatment of unruptured intracranial aneurysms using Dual versus mono-Antiplatelet therapy Randomized Trial

DeFat

Defatting of donor transplant livers during normothermic perfusion – a randomised clinical trial

DEFINE

Digital thErapy For Improved tiNnitus carE Study

DEPTH

Dapagliflozin during exercise for the prevention of Hypoglycaemia in Type 1 diabetes – Pilot study

DESPIAD

Depletion of Serum Amyloid P Component In Alzheimer’s Disease

DESPIAD DATABASE

DETA

Dapagliflozin, Exercise Training and physicAL function: the DETA trial

DeVA

Improving Outcomes in Fistula Intervention: A prospective, patient blinded, phase 3, randomised controlled trial of Drug Eluting Balloons in the Angioplasty of Native Haemodialysis Access Arteriovenous Fistula Outflow Stenosis

DIADEM-1

Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial assessing the impact of low calorie diet and activity on body weight and glycaemia in diabetes in early diabetes

DIAMONDS

DIAbetic Macular Oedema aNd Diode Subthreshold micropulse laser

DIAS-001-FFR

An Investigation to Evaluate an Over-The-Wire FFR Infusion Microcatheter (HYPEREM™IC) for Measuring Fractional Flow Reserve (FFR)

DIASTOLIC

Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular dysfunction

DIBS

A pragmatic, multicentre, placebo-controlled, 3-arm, double-blinded, randomised controlled trial, incorporating an internal pilot, to determine the role of bronchodilators in preventing exacerbations of bronchiectasis

DIGEST

Digital Diabetes Remission Trial

DISC

A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients.

DISCO

DIrect or Subacute COronary angiography in out-of-hospital cardiac arrest – a prospective, randomized study

DIvO

Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital imaging? The Digital Imaging versus Ophthalmoscopy (DIvO) study

DMPA_XT

OpenClinica

DOLAB II

Published

The DHA (docosahexaenoic acid) Oxford Learning and Behaviour (DOLAB II) Study. Does taking an Omega 3 food supplement help children’s learning and behaviour?

DOSA

Randomised controlled trial of nasal decongestants versus placebo to prolong treatment free periods from continuous positive airway pressure therapy in mild to moderate obstructive sleep apnoea

DREAMS START

A parallel multi-centre randomised controlled trial to determine the clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carers

Dry eye syndrome

A Phase II, multicentre, randomised, placebo-controlled, double-masked trial of RP101 ophthalmic formulation versus vehicle in post-menopausal women with moderate to severe dry eye syndrome

DyeVert

DyeVert TP-6495 trial. Mobius Medical Pty Ltd, Australia

EASE

A randomized, double-blind, placebo-controlled, 2 period, crossover study to evaluate the efficacy and safety of ATX01 (topical amitriptyline hydrochloride 15% w/w) in adult patients with pain due to erythromelalgia (EM)

EASI-SWITCH

Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis.

EASY-AS

A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis (EASY-AS)

EBI-LD

A feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the community

ECLAD

ECST-2

The second European Carotid Surgery Trial. ECST-2 (ISRCTN 97744893) is an international randomised trial comparing the treatment of mild to moderate carotid stenosis by optimized medical management alone with carotid surgery or stenting and optimized modern medical management.

EDEN

Erythropoietin and Darbepoetin in Neonatal Encephalopathy

Effect of d-cycloserine on brain processing of breathlessness

Understanding the importance of plasticity in the brain mechanisms of dyspnoea perception

ELECT2 Trial

EarLy Exercise in blunt Chest wall Trauma: a mixed methods, multi-centre, parallel randomised controlled trial

EMBIO

EMBRACE

Erythropoietin Monotherapy in Neonatal Encephalopathy in Low and Middle-Income Countries

EMERGE

A Randomised Placebo Controlled Trial of the effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects

EMPIRIKAL

An Investigation into the efficacy of Mirococept (APT070) for preventing ischaemia-reperfusion injury in the kidney allograft (EMPIRIKAL). King's College London and Guy's & St Thomas' NHS Foundation Trust.

ENHANCE-D

ENHANCE-D: Enhancing Dental Health Advice

ENT02UK

Randomised, multi-centre study to assess efficacy, tolerability and safety of Enterosgel® in treatment of acute diarrhoea in adults

EPARCAR

EPICC-ID

Evaluation of Parent Intervention for Challenging Behaviour in Children with Intellectual Disabilities

ERIC-GTN

The effect of remote ischaemic preconditioning and glyceryl trinitrate on peri-operative myocardial injury in cardiac bypass surgery patients (ERIC-GTN study) - a four arm randomised, controlled trial.

ERIC-PPCI

Published

Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI): A multicentre randomised controlled clinical trial

ERICCA

Published

Effect of Remote Ischaemic preConditioning on clinical outcomes in patients undergoing Coronary Artery Bypass Graft surgery. A multicentre randomised controlled clinical trial to determine whether remote ischaemic preconditioning (RIC) improves clinical outcomes after cardiac surgery.

ESAS

Equally Safe at School

EVIAN

A Feasibility RCT of Early Vitrectomy and Intravitreal Antibiotics for post-operative exogenous eNdophthalmitis (EVIAN)

EVNP

A Randomised controlled, open label trial of Ex-vivo Normothermic Perfusion versus Static Cold Storage in Donation after Circulatory Death Renal Transplantation

EVOCC

A randomised controlled trial assessing the clinical and cost- effectiveness of Endovascular vs. Open revascularisation in severe oCClusive aorto-iliac disease. The EVOCC Trial

Exenatide

Published

A randomised, double blind, placebo controlled, single centre, 60 week, trial of Exenatide for the treatment of moderate severity Parkinson's disease.

Exenatide MSA

A Phase IIa, open label, single-site, 48 week randomised controlled trial evaluating the safety and efficacy of Exenatide once-weekly in the treatment of patients with Multiple System Atrophy

ExOS

A comprehensive comparison of the sensitivity of common exercise outcome measures for Chronic Obstructive Pulmonary Disease (COPD).

EXTOD

Supporting adults with Type 1 Diabetes (T1DM) to undertake exercise; Developing and piloting an Education programme for exercise in Type 1 diabetes: EXercise for Type 1 Diabetes (EXTOD) education

EXTOD-Active

The effect of interrupting sitting with regular active breaks on glycaemia and daily insulin dose in sedentary people with type 1 diabetes

FACT

A Randomised Comparison of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.

FENETRE

Quality-Assured Follow-up of quiescent neovascular age -related maculaR dEgeneration by non-medical practitioners: a randomised controlled trial

FEVER

A multi-centre, pilot, randomised clinical trial of a more permissive temperature threshold for antipyretic intervention in critically ill children with known or suspected infection

FIRST-ABC

FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): A master protocol of two randomised trials to evaluate the non-inferiority of high flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in paediatric critical care

Fisetin Dosing Study

Fisetin Dosing Study

FLAMINGO

Feeding in Late and Moderately Preterm Infants and Growth Outcomes

FLARE

Favipiravir, lopinavir/ritonavir or combination therapy: a randomised, double blind, 2x2 factorial placebo- controlled trial of early antiviral therapy in COVID-19

FLASH-UK

An open-label, multi-centre, randomised, parallel design study to assess the efficacy of flash glucose monitoring in adults with type 1 diabetes

FLICOR

FLO-ELA

Open, multicentre, randomized controlled trial of cardiac output-guided haemodynamic therapy compared to usual care in patients undergoing emergency bowel surgery

FLORA

Fibre Supplements For Pre-diabetes

FMS

Published

Randomised Feasibility Study of a Physiotherapy Programme for Patients with Functional Motor Symptoms (FMS).

FOCUS Poland

Fluoxetine Or Control Under Supervision Poland. A randomised trial to establish the effect(s) of routine administration of Fluoxetine in patients with a recent stroke in Poland.

Foot-PAD

The Foot-PAD trial: Effect of a footplate muscle stimulation program on walking capacity in people with Peripheral Artery Disease

FRACTAL

A phase IIa, randomized, 2-arm parallel-group, placebo-controlled, double-blind, multi-centre trial to evaluate safety, tolerability, anti-inflammatory and cardio- protective effects after intravenous and oral administration of KAND567 in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention

FreeDM2

FROST 1

Finding the optimal cooling tempeRature after Out-of-hoSpiTal cardiac arrest. Zoll Circulation Inc.

Ft Hood TBI

Using Real-Time Functional Brain Imaging to Enhance Recovery from TBI. The Geneva Foundation.

Furlong

Enrolment of patients to a Prospective Multicentre Clinical Surveillance Study To Evaluate The Stability, Efficacy And Safety Of The Furlong Evolution® Hip Stem In Primary Total Hip Arthroplasty.

GASTRIC-PICU

GECo

Implementation of COPD Case Finding and Self-Management Action Plans in Low and Middle Income Countries

GL1v3

The Glooko Diabetes Mobile Monitoring and Management Advantage Study (GL1v3)

GL3

Insulin degludec titration using mobile insulin dosing system

GLOBIFER-HF

Globifer Forte® Oral Haem and Non-haem Iron Supplementation in Heart Failure

GLYDE

A comparison of Glycosade® and Uncooked Cornstarch (UCCS) for the dietary management of hepatic glycogen storage diseases (GSD

Graves-PCD

Randomised controlled trial of plasma cell depletion for severe Graves’ disease

GridCircular

Comparative study of Advisor HD Grid versus Circular Mapping Catheters in assessment of pulmonary vein isolation following previous ablation for Atrial Fibrillation

GUARDS

Two-armed, double blind, randomised, controlled trial with ursodeoxycholic acid (UDCA) versus placebo for the treatment of Gestational Diabetes Mellitus (GDM)

H-Prime

Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden

Halt-it

Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial

HAPLO+4Kids

HART

Published

Hughes Abdominal Repair Trial

HEAL

Published

HEAL trial - Hepatic Encephalopathy And LOLA. Efficacy of intravenous 'L-ornithine L-aspartate' in reversal of overt acute hepatic encephalopathy in patients with liver cirrhosis: a prospective, randomized, double-blind, placebo controlled trial.

HEART

Healthcare Evaluation of Absolute Risk Testing: A multi-centre, single arm, pragmatic study in primary care setting

HELIX

Published

Hypothermia for Encephalopathy in Low and Middle-Income Countries (HELIX) trial

Help-Diabetes

Published

Randomised controlled trial of a web-based self management programme (HeLP-Diabetes) for people with type 2 diabetes in primary care.

Help-Diabetes implementation study

Hi-Spec

A multicentre randomised controlled trial to evaluate the effect of Heimlich valves on length of stay in patients admitted to hospital with secondary spontaneous pneumothorax.

HIPvac

Human papillomavirus infection: a randomised controlled trial of Imiquimod cream (5%) versus Podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts.

HIV-CORE003

Published

A randomised double-blind, placebo-controlled phase I/IIa trial to investigate the effect of depletion of serum amyloid P component (SAP) on the immune response to DNA vaccination in healthy male volunteers.

HomeHealth

Clinical and cost-effectiveness of an in- home personalised health promotion intervention enabling independence in older people with mild frailty (‘HomeHealth’): A Randomised Controlled Trial

Hope-ICU

Published

HalOPeridol Effectiveness trial. A randomised, double-blind, placebo-controlled trial to compare the early administration of intravenous haloperidol versus placebo in the prevention and treatment of delirium in critically ill ventilated patients.

HOTDECAF

Randomised controlled trial of hospital at home directed by the DECAF score versus standard inpatient care for patients admitted with an acute exacerbation of COPD and embedded health economic and qualitative studies.

IASO

A phase II randomised placebo controlled double blinded trial of Interleukin 1 blockade in Acute Severe Colitis

ICE-T

Iron and Chronic Obstructive Pulmonary Disease COPD Exercise Trial. To test the hypothesis that intravenous iron improves exercise performance in COPD as measured by constant rate cycle ergometry.

ICONS II

ICONS II - Identifying Continence OptioNs after Stroke randomized controlled trial

ID-078-118 Stand-alone unblinding

ID-091-101 Stand-alone unblinding

A single-center, double-blind, randomized, placebo-controlled Phase 1 study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses of IDOR- 1117-2520 in healthy subjects

IDEAL

Kidney Disease in Type 2 Diabetes Mellitus: Biomarker Discovery and Novel Therapeutics.

Impact

Published

Improving Mood with Psychoanalytic And Cognitive Therapies. Trial of Specialist Clinical Care (SCC) vs. Cognitive Behavioural Therapy (CBT) vs. Short Term Psychoanalytical Psychotherapy (STTP).

IMPEDE-PKD

Implementation of Metformin theraPy to Ease Decline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD) Randomised Placebo-Controlled Trial

Improve

Published

The Immediate Management of the Patient with Ruptured Aneurysm: Open Versus Endovascular repair. Imperial College, London.

INDIGO

Interactions between the diet and gut microbes, metabolism and body composition in preterm infants

INFORM AIM-HY

ComparIsoN oF Optimal Hypertension RegiMens (Part of the Ancestry Informative Markers in Hypertension (AIM HY)

Insight

IL-6 Inhibition in Patients with Depression and Low-grade Inflammation: The Insight Study

INTERIM

INTERIM: a randomised phase II feasibility study of INTERmittent versus continuous dosing of oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma

Intravenous iron in COPD

Effects of intravenous iron in COPD

Iovera Study

IPC-PLUS

The efficacy of Indwelling Pleural Catheter placement versus IPC placement PLUS sclerosant (talc) in patients with malignant pleural effusions managed exclusively as out-patients.

iPREVENT

Increase in colonic PRopionate as a method of prEVENTing weight gain in young adults

iROC

A phase III multicentre randomised controlled trial to compare the efficacy of Robotically Assisted Radical Cystectomy and intracorporeal urinary diversion with Open Radical Cystectomy in patients with bladder cancer.

ISAP

ISO-SHOCK

Incorporating Supersaturated Oxygen in Shock

IST-ID Study

Clinical and cost evaluation of intensive support teams (IST) for adults with intellectual disabilities and challenging behaviour

IVON

Intravenous versus oral iron for iron deficiency anaemia in pregnant Nigerian women (IVON): an open label, randomized controlled trial

IVON-PP

Intravenous ferric carboxymaltose versus oral ferrous sulphate for the treatment of moderate to severe postpartum anemia in Nigerian women (IVON-PP): an open label randomized controlled trial alongside an implementation study

IVORY

Low-dose interleukin-2 for the reduction of vascular inflammation in Acute Coronary Syndromes

Ixion

Jejunostomy Pilot

Investigating the effect of post-operative home jejunostomy tube feeding on quality of life and nutritional parameters in patients with oesophago-gastric cancer: A pilot study

KARE

Clinical trial examining the effect of ketamine in combination with CBT on relapse rate in alcoholics.

KERALINK

Corneal cross-linking versus standard care in children with keratoconus; a randomised, multicentre, observer-masked trial of efficacy and safety

KIWE

Ketogenic diet in infants with epilepsy (KIWE)

LASER

A multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly-controlled, severe allergic asthma.

LatinMH

Randomized Controlled Trial to evaluate the effectiveness of an intervention using mobile technology for the treatment of depressive symptoms in people with diabetes and/or hypertension

LCDDM

A Randomised Controlled Trial Assessing the Impact of a Low Calorie Diet on Weight Loss in Obese Patients with Type 2 Diabetes Mellitus Treated with Insulin.

LEAP

Published

The aim of this study is to determine the efficacy of a novel therapy in the treatment for anorexia nervosa (AN), namely the Loughborough Eating disorders Activity theraPy (LEAP). LEAP is an innovative therapy that addresses the role of extreme exercise in the maintenance of AN using cognitive techniques and behavioural experiments and is fully integrated with an established manualised cognitive behavioural therapy for AN (mCBT-AN).

LiGHT

Published

Health-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy.

LiGHT China

Health-Related Quality of Life in two treatment pathways for newly diagnosed open angle glaucoma and ocular hypertension: an unmasked, multi-centre randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy

Little Journey

A Multi-site randomised controlled trial assessing the effectiveness of the Little Journey app at reducing peri-operative anxiety compared to standard care.

Losartan Study

Losartan TKA

LOSE-AF

Weight Loss in Elderly Patients with Atrial Fibrillation (LOSE-AF): A Randomised Controlled Study

Lung Screen Uptake Trial

A Randomised Controlled Trial to test novel invitation methods and materials targeted to increase INFORMED uptake of lung cancer screening in individuals at high risk of lung cancer.

Lutathera

Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications Including Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/Phaeochromocytoma, Medullary Thyroid Carcinoma, and Those Requiring Repeat Peptide Receptor Radionuclide Therapy

LYDIA

Impact of Liraglutide on cardiac function and structure in young adults with type 2 diabetes: an open-label, randomised active-comparator trial.

M3

The impact of a holistic multifactorial management intervention in adults with early-onset type 2 diabetes (aged 16 to 45 years): The M3 randomised controlled trial. Might involved second randomisation as a SWAT

Mag Cool Study

Published

A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia plus Magnesium Sulphate (MgSO4) vs. Therapeutic Hypothermia plus Placebo in the management of Term babies with Hypoxic Ischemic Encephalopathy. Hamad Medical Corporation.

MAGIC

MARQUE WP6

Managing Agitation and Raising Quality of Life: feasibility trial of an intervention to improve the management of agitation in severe dementia

MARS 2

A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma. Papworth Hospital, Cambridge.

MAST Trial - DURATION

Pharmacological management of seizures post traumatic brain injury – Duration

MAST Trial - PROPHYLAXIS

Pharmacological management of seizures post traumatic brain injury – Prophylaxis

MATE

Treating neovascular age-related Macular degeneration with Aflibercept: a pilot 24 month, multi-centre randomised controlled trial comparing Standard Care with an individualised Treat and Extend regimen.

MATIS

Multi-arm trial of Inflammatory Signal Inhibitors for COVID-19

MBCT-vision VSS RCT study

MBCT-vision to treat Visual Snow Syndrome: a Randomised Controlled Trial

MELD-ATG

Phase II, dose ranging, efficacy study of anti-thymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes (T1D)

MEND

A phase III, randomised, double blinded, headto-head, single-site, cross-over trial of lamotrigine versus mexiletine for nondystrophic myotonias (MEND)

MePFAC

Methylphenidate versus placebo for fatigue in advanced cancer

Merck Malaria - Capture 1

MERIT

Metformin for treating peripheral artery disease-related walking impairment

MeRT-005-B

MesoTRAP

A pilot clinical trial and feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a Phase III trial

MET-PREVENT

Metformin to prevent progression of sarcopenia and frailty in older people – a double blind, randomised controlled proof of concept trial

METFINGER 1

METFINGER 2

mHealth Advantage

Diabetes Mobile Monitoring and Management Advantage Study

MIAMI

Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local breast cancer recurrence? 
A randomised controlled feasibility study.

MICE

Mental Health Intervention for Children with Epilepsy

MILO

Membrane Sweeping for Induction of Labour – The MILO Study

MIMICH

Metformin Impact on Maternal and Infant Cardiometabolic Health

MINIMISE STEMI

MINeralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-Elevation Myocardial Infarction (STEMI).

MINIMISE-Pilot

Mycophenolate in limited cutaneous systemic sclerosis A randomised prospective open label pilot trial comparing mycophenolate mofetil with no immunosuppression in adults with limited cutaneous systemic sclerosis

MINT

A randomized controlled trial of M.I.P.O. vs Intramedullary Nailing in fractured Tibias. The trial is being carried out at the Department of Surgery, King Abdul Aziz Medical City & King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

MiPEP

Published

Maraviroc in HIV Post Exposure Prophylaxis (MiPEP) Trial. Randomised controlled trial of the tolerability and completion of maraviroc compared to Kaletra in combination with Truvada for HIV post-exposure prophylaxis.

MitoDCM

MOSAICC

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury and metabolic acidosis Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care (MOSAICC)

MRB Study

Managing Repetitive Behaviours: A clinical and cost effectiveness trial of a parent group intervention to manage restricted and repetitive behaviours in young children with Autism Spectrum Disorder

MRC-ILA-HEART Study

Published

A proof of concept clinical trial investigating the effects of IL-1ra upon markers of inflammation in patients with Non-ST elevation myocardial infarction.

MS-OPT

SIMVASTATIN IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS - A double-blind, randomised, placebo-controlled multi-site study of high dose simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage

MS-STAT2

A phase 3 randomised, double blind, clinical trial investigating the effectiveness of repurposed simvastatin compared to placebo, in secondary progressive multiple sclerosis, in slowing the progression of disability

Multivessel TALENT

A randomized controlled trial to compare the safety and efficacy of siroliMUs-eLuTIng biodegradable polymer ulTrA-thin stent (SUPRAFLEX™ Cruz) and everolimus- eLuting biodegradable polymer stent (SYNERGY™) in treatmENT for three-vessel coronary artery disease: Multivessel TALENT

MUSE

Managing Unusual Sensory Experiences (MUSE): A feasibility trial of a targeted, psycho-education toolkit for distressing hallucinations, in people with a first episode of psychosis.

MUSE ARMS Feasibility Trial

MUSE ARMS Feasibility RCT: A feasibility trial employing a prospective randomised, open- label, observer blinded, endpoint design assessing a targeted, computer/web based guided self-help psycho-education toolkit for distressing hallucinations (MUSE) +treatment as usual (TAU) compared to a time matched TAU, offered by a multi-disciplinary team which includes emotional support, psychoeducation and stress management, aiming to reduce distress from hallucinations and improve functioning, , in people with an At Risk Mental State (ARMS) for psychosis in UK secondary care mental health services.

MVO

Published

Randomized Controlled Trial Comparing Intracoronary Administration of Adenosine or Sodium Nitroprusside to Control for Attenuation of Microvascular Obstruction During Primary Percutaneous Coronary Intervention.

MVX01-01

MXU Peer Study

The TB Reach MXU Peer Study. A cluster randomised controlled trial evaluating the impact of peer educators on uptake of MXU screening for TB among homeless populations.

NAMinG

Nicotinamide in Glaucoma (NAMinG): A randomized, placebo-controlled, multi-centre, Phase III trial

NanoStrand

Comparison of Early Fusion in Anterior Cervical Decompression and Fusion (ACDF) with OsteoStrand™ Demineralized Bone Fibres and Cambria™ NanoMetalene® Implant Compared to Cabmria Uncoated Implant

NEON

Amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised controlled trial of Nutritional Evaluation and Optimisation in Neonates.

NerveCap

A multicenter, prospective, randomized and subject blinded comparative study of AxoGuard Nerve Cap and Neurectomy for the Treatment of Symptomatic Neuroma and Prevention fo Recurrent End-Neuroma Pain

Neuroprotection with phenytoin in optic neuritis

Published

A phase II double-blind, randomised, placebo controlled trial of neuroprotection with phenytoin in acute optic neuritis. Sponsored by UCL and funded by the National Multiple Sclerosis Society and the Multiple Sclerosis Society of Great Britain and Northern Ireland.

NeuroSAFE

A single blinded, multi-centre site, feasibility study to evaluate the ability to randomise men with prostate cancer into a trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard Robotic assisted radical prostatectomy (RALP)

NIDUS-Family

Clinical and cost-effectiveness of a New psychological intervention to support Independence in Dementia (NIDUS) for family carers and people living with dementia in their own homes: A randomised controlled trial

NIDUS-Professional

Feasibility of the NIDUS-professional home carer training intervention

NightLife

A randomised controlled trial assessing the effectiveness and cost effectiveness of thrice weekly, extended, in-centre nocturnal haemodialysis versus standard care using a mixed methods approach

NIVOW

Non-Invasive Ventilation Outcomes score- directed Weaning (NIVOW) - Standard versus accelerated weaning from non- invasive ventilation (NIV) in chronic obstructive pulmonary disease directed by the NIV outcomes score: a randomised controlled trial

NMES-DN

Neuromuscular Electrical Stimulation For The Treatment Of Diabetic Neuropathy: A Multi-centre, Double-blind, Pilot, Randomised, Sham-controlled Trial (NMES-DN)

NorAD

NOTACS

Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Study: Effect of High-Flow Nasal Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial

Nu-V3P2RCT

Nutritech

New technologies and tools to nutrition research - the example of phenotypic flexibility. Department of Investigative Medicine, Imperial College.

OACS-1

Obeticholic Acid for the Amerlioration of Cognitive Symptoms trial -1

OACS-2

Obeticholic Acid for the Amerlioration of Cognitive Symptoms trial (OACS-2)

ObiVas

A randomised, phase II, double blind, controlled mechanistic study of obinutuzumab versus rituximab in ANCA-associated vasculitis

Octreotide Trial

A double-blind randomised placebo-controlled feasibility study to assess the impact of octreotide infusion during liver transplantation on post-operative renal failure

OFORT003

OFORT003 - Lyophilized Amniotic Fluid

OnPace

OPACE

Optimising azithromycin prevention treatment in COPD to reduce exacerbations (OPACE): A double blind adaptive design pragmatic phase IV randomised controlled trial

OPERA

Optimising Primary Therapy in Primary Biliary Cholangitis

OPTIMA RCT

Online Parent Training for The Initial Management of ADHD Referrals: A two-arm parallel randomised controlled trial of a digital parenting intervention implemented on a treatment waitlist.

OPTIMAL

The holistic peripheral artery disease management trial

OPTIMAS

OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial

OR30.2019.10

Prospective, Multi-center, Randomized, Controlled Study to Evaluate the Safety and Efficacy of the OR3O™ Dual Mobility System versus conventional single bearing design Total Hip System in Primary Total Hip Arthroplasty (THA) Procedures

ORBIT

Published

Therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents with Tourette syndrome: an internal pilot study and single-blind randomised controlled trial

ORTIZ

A Multi-site, placebo controlled, double blind randomised clinical trial evaluating the effectiveness of sodium zirconium cyclosilicate versus placebo to enable safe optimisation of RASi therapy in patients with diabetic kidney disease

OUTREACH

BiOmarkers in Urine, anTihypeRtensive trEAtment and blood pressure Control in Hypertensive patients

OxPiC

Investigating the effects of a prebiotic supplement on learning and behaviour in children from academic year groups 3, 4 and 5, whose reading scores suggest there is room for improvement: a randomised placebo-controlled study. University of Oxford.

Oxy-PICU

A Randomised Pilot Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children

Oxy-PICU Full Trial

A Randomised Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children

P-VECT

Peri-Vascular adipose tissue inflammation Evaluated using coronary CT angiography (P-VECT Study)

P4KC

Prepare for Kidney Care: a randomised controlled trial of preparing for responsive management versus preparing for renal dialysis in advanced kidney disease

PAciFY Cough

PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough

PANDA

What are the indications for Prescribing ANtiDepressAnts that will lead to a clinical benefit? A Phase IV, double-blind randomised placebo-controlled, parallel group multi-site trial; of sertraline compared to placebo in patients presenting with depressive symptoms in primary care where treatment with SSRIs is uncertain.

PANDA-Dose

A Pilot Clinical Trial to Test the Acceptability and Feasibility of Oral Iron Supplementation in pregnant women

PAPMAT

Positive Airway Pressure plus Mandibular Advancement Therapy

Parents in conflict

Effectiveness of a Mentalization-based therapeutic intervention for parents in conflict over their children: a randomised controlled trial. Coordinated by The Tavistock Centre for Couple Relationships (TCCR).

Partner

Partner: Platinum & Parp-Inhibitor for neo-adjuvant treatment of Triple Negative and/or BRCA Positive Breast Cancer

PATHFINDER

Problem Adaptation Therapy for individuals with mild to moderate dementia and depression

pAVK

Promoting home-based walking exercise using telephone-based health coaching and activity monitoring for patients with peripheral artery disease (TeGeCoach)

PAX-BD

A randomised, double-blind, placebo controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression.

PBS

Evaluation of Positive Behaviour Support (PBS). Randomised controlled trial to evaluate the clinical and cost effectiveness of PBS following standardised training of staff in routine clinical practice in community intellectual disability services.

PD-Care

Live Well with Parkinson’s (as part of the program Personalised care for people with Parkinson’s Disease: PD-Care)

PELVIVA

Primary care evaluation of a novel disposable neuromuscular electrical stimulation treatment for urinary incontinence: A randomised controlled trial

PERFORM FEASIBILITY Trial

Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multi-morbidity) PERFORM: Feasibility study

PETAL

A randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates

PETAL Study

Personalised treatment packages for adults with learning disabilities who display aggression in community settings: a cluster randomised controlled trial Cluster randomised trial

PETRA

PrEgabalin for Treatment Resistant generalised Anxiety disorder

PHANTOM RELIEF

An investigation of the efficacy of a novel sensory discrimination training device for the management of phantom limb pain: A randomised, single-blind, placebo-controlled trial.

Phoenix

Phoenix VR Self-Confidence Study

PHOSP-COVID Rehab

PHOSP-COVID - Rehabilitation for lasting symptoms of COVID-19

Physio4FMD

A randomised feasibility study of specialist physiotherapy for functional motor disorder

PhytoSERM-HF

PIMS

PIONEER

Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer

PiPS2

The Prognosis in Palliative care Study II (PiPS2): A multicentre prospective, observational, validation cohort study.

PIPSICKLE

Low dose aspirin for the prevention of intrauterine growth restriction and preeclampsia in sickle cell pregnancy: a randomised controlled trial

PITSTOP

PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients: a Feasibility Study

PlaNeT-2

Platelets for Neonatal Transfusion (PlaNeT) study 2. A trial to compare two platelet transfusion thresholds, and establish whether a lower platelet transfusion threshold is as safe as a higher threshold.

PLUTO

PlasmaLyte Usage and kidney Transplant Outcomes in children

POLYFIX-DCM

Posterior Laminectomy and FIXation for Degenerative Cervical Myelopathy

POMS 2b Adult

POMS2b: Prevention of Morbidity in Sickle Cell Disease (Phase II)

POMS 2b Child

POSITIVE

Problem-solving intervention for people who have been recently diagnosed as blind or partially-sighted. The primary aim of this trial is to determine whether blind and partially sighted people who undertake Problem-Solving Treatment (PST) demonstrate better psychological well-being, mobility and quality of life than those undergoing usual care (rehabilitation).

POWAR

POWAR Study (Prophylaxis Of Wound infections - Antibiotics in Renal donation). Are prophylactic antibiotics necessary before laparoscopic living kidney donation? A double blind, randomised, controlled trial.

PRE-OP ENERGY

A randomised controlled trial of pre-operative high energy diet for the prevention of organ injury in cardiac surgery: The PRE-OP ENERGY Trial

PredictPREV

Evaluating web based information for prevention of depression in general practice: an exploratory randomised controlled trial.

PREMISE

PREMIUM

PREMIUM - PeRioperative Encorafinib+binimetinib in BRAFV600 MUtant clinically detected AJCC stage III (B/C/D) or oligometastatic stage IV Melanoma

PrEPS

Prehabilitation in Elective Patients undergoing cardiac Surgery

PRESSURE

Evaluating the clinical and cost effectiveness of using a permissive blood pressure target to guide titration of vasoactive drugs in critically ill children with hypotension. PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE

PRESTARt

PREvention STrategies for Adolescents at Risk of diabetes - A pilot study across 5 European countries.

PREVENT

A randomised, multicentre post-exposure prophylaxis (PEP) clinical trial evaluating RESP301, an inhaled therapy for treatment of lung infections, for prevention of onward transmission of viral infections including SARSCoV-2 to household members. (PREvent Viral Exposure aNd Transmission study: a SARS-CoV-2 PEP Study -PREVENT)

PREVENTION HARP-2

Prevention Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction

PREVENTT

A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery.

PRIME RCT

PRIMROSE

Prediction and management of cardiovascular risk for people with severe mental illnesses.

PRO2TECTION 1 Trial

Pulmonary protection with low frequency ventilation during cardiopulmonary bypass: a prospective randomised study.

PROACT

Preventing cardiac damage in patients treated for breast cancer and lymphoma: a phase 3 Randomised, Open label, blinded endpoint, superiority trial of enalapril to prevent Anthracycline-induced CardioToxicity

PROBLANE

Impact of anatomical bladder neck preservation on functional and oncologic outcomes after robotic-assisted laparoscopic radical Prostatectomy

PROCTOR

PeRcutaneous cOronary intervention of native Coronary arTery versus venous bypass graft in patients with prior cORonary artery bypass graft surgery - the PROCTOR trial

PRODOSE

Algorithmic Protamine Dosing for Reversal of Heparin after Cardiopulmonary Bypass (PRODOSE)

PROFILE

PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr trial

PROHIBIT-ICH

PROLIFIC

ChemoPROphyLaxIs For covId-19 infeCtion (the PROLIFIC trial)

PROMOTE

Pain Reduction with Oral Methotrexate in knee Osteoarthritis, a pragmatic phase III trial of Treatment Effectiveness

PROMOTE UC

Pro-active fecal calprotectin monitoring to improve patient outcomes in ulcerative colitis: a prospective randomised control trial

PRoMPT (NHS Blood and Transplant)

Published

Platelet Responsiveness and Outcome from Platelet Transfusion. Does inherent variation in donor platelet function affect the clinical efficacy of apheresis platelets? A randomised double blind single centre trial.

PROPELS

The PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for those with prediabetes (PROPELS) - randomised controlled trial in a diverse multi-ethnic community.

PROTECT

IRST100.47 - PROTECT

PROTECT-V (Cambridge)

PROphylaxis for paTiEnts at risk of COVID-19 infecTion (PROTECT-V)

Protect-V Monoclonals

PROTECTHF

Protocolised Management in Sepsis (ProMISe)

Published

A multi-centre, randomised controlled trial of the clinical and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock.

Pulmicc

A Randomised trial of Pulmonary Metastasectomy in Colorectal Cancer. This is a two-stage randomised feasibility study. Patients will be firstly registered for evaluation and if subsequently eligible, randomised to active monitoring versus active monitoring with pulmonary metastasectomy.

QDMAT

Qatar Diabetes Mobile Application Trial

QPS 160382

160382 Dr Reddy's - Oral DFD-29 for the Treatment of Rosacea

RADAR

Published

Reducing pathology in Alzheimer's Disease through Angiotensin taRgeting. University of Bristol School of Social & Community Medicine

RADARp

Research into Antipsychotic Discontinuation and Reduction

RadBone

Bone Toxicity following Pelvic Radiotherapy: A prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecological cancers undergoing pelvic radiotherapy

RAPID NSTEMI

A randomised controlled trial of very early versus delayed angiography +/-Intervention on outcomes in patients with non ST-elevation myocardial infarction

RAPID-TEST

RAPS

Published

Rivaroxaban in Antiphospholipid Syndrome (RAPS) Trial (EudraCT 2012-002345-38).

Reach to grasp

Published

Pilot study for a randomised controlled trial of home based reach to grasp training for people after stroke.

REACT

A randomised study of interferon-free treatment for recently acquired hepatitis C in people who inject drugs and people with HIV coinfection (REACT)

ReCCLAIM-II

REperfusion with Cooling in CerebraL Acute IscheMia II

RECEDE

Regeneration in Cervical Degenerative Myelopathy - a multi-centre, double-blind, randomised, placebo controlled trial assessing the efficacy of Ibudilast as an adjuvant treatment to decompressive surgery for degenerative cervical myelopathy

REDJUVENATE

A randomized controlled trial of red cell rejuvenation for the attenuation of transfusion associated organ injury in cardiac surgery: the REDJUVENATE trial

REDUCE

A randomised controlled trial evaluating the efficacy of indwelling pleural catheters in persistent non-malignant symptomatic pleural effusions.

REDUCe2

Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial

REDWASH

Published

A randomised controlled trial of red cell washing for the attenuation of transfusion associated organ injury in cardiac surgery.

REFINE-Lung

REGENETEN

A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Efficacy of ARCR augmented with REGENETEN Bioinductive Implant System in Full-thickness Tears (large or massive) Repair versus ARCR alone

Regeneten.2021.04

Evaluation of safety and efficacy of a resorbable collagen implant in treatment of high grade partial thickness tears; a prospective, multicenter, randomized, control trial (IMPACT study)

REJOIN

The REJOIN study (REhabilitation for Job and Occupational INdependence) – a feasibility study of a randomised controlled trial to evaluate a vocational rehabilitation intervention for people with cancer.

RELIEF

The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial.

RELIEVE IBS-D (ENT04UK)

Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel® in the treatment of Irritable Bowel Syndrome with Diarrhoea (IBS-D) in adults (RELIEVE IBS-D)

REMEDY PILOT

ReMIND

A randomized trial of Rituximab in induction therapy for living donor renal transplantation. This is a Phase IV randomised, open label, controlled trial.

REMOTE-ILD

Comparison of clinical effectiveness and cost-effectiveness of a remote monitoring programme versus usual care in Interstitial Lung Disease

Renew NCP-5-1001

KAI Research, Inc.

Repair

Published

Randomised double blind placebo-controlled trial to determine if remote ischaemic preconditioning (RIPC) improves renal function after transplantation.

RESOLVE

RESPECT-meso

A multicentre, non-blinded, randomised controlled trial to assess the impact of Regular Early SPEcialist symptom Control Treatment on quality of life in malignant Mesothelioma – “RESPECT-Meso”

RESPONSE

RESPONSE: REmediation of SPatial NEglect Trial. Posit Science.

REST

pRotective vEntilation with veno-venouS lung assisT in respiratory failure

REVAKI-2

The Effect of Sildenafil (REVATIO®) on Post Cardiac Surgery Acute Kidney Injury (AKI): A Randomised, Placebo-controlled Clinical Trial.

REVIVED-BCIS2

Revascularisation for Ischaemic Ventricular Dysfunction - a multicentre prospective randomised open controlled trial. The aim is to evaluate the efficacy and safety of percutaneous coronary intervention compared to optimal medical therapy alone for ischaemic left ventricular dysfunction.

RIO

RIPC

Remote ischaemic preconditioning for brain protection in paediatric cardiac surgery. This trial is run by UCL Institute of Cardiovascular Science & Great Ormond Street Hospital.

RISAPS

Rivaroxaban In Stroke patients with AntiPhospholipid Syndrome

Rosa

Retinopathy and OSA Trial. A randomised controlled trial of Continuous Positive Airway Pressure in patients with impaired vision due to diabetic retinopathy and concurrent Obstructive Sleep Apnoea. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).

SAFE-LCD

Sahara Study

An Evaluation of the Safety and Effectiveness of the N-SWEAT Patch for the Treatment of Primary Axillary Hyperhidrosis or Excessive Axillary Sweating

Salbutamol Study

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Brighton & Sussex University Hospitals NHS Trust

Sandman

A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease

SATIN

Code break application for the Symptomatic versus Antibiotic Treatment of urinary tract INfection trial.

SBRI-LTx

An Evaluation of Remote Care (Questionnaire+Hybrid) in Patients Who Are Post-lung Transplant

SC IL-1RA in SAH

A double blind randomised controlled trial to determine whether IV administered Kineret® inhibits the central nervous system (CNS) inflammatory response in patients with SAH

SCANMOVE

A novel diagnostic screening procedure for antipsychotic-induced movement disorders.

SCIMITAR

Smoking Cessation for Severe Mental Ill Health Trial

SCONE Clinical Study

Transformation of Dormant Spinal Networks to Mitigate Symptoms of Neurogenic Bladder (“SCONE Clinical Study”)

SCOPE-BD

A Randomised Double-Blinded Placebo- Controlled Trial to Assess the Efficacy and Safety of Scopolamine Compared to Placebo in Individuals with Bipolar Disorder who are Experiencing a Depressive Episode

SCORE/CHAMPION2

A randomized controlled trial of remedial after-school support classes in rural Gambia

SCRATCH-HTN

Sham controlled Randomized Control Trial evaluating the Safety, Acceptability and Efficacy of Autonomic neuromodulation using trans-cutaneous vagal sensory stimulation in uncontrolled hypertensive patients: a pilot study (SCRATCH –HTN)

SEESAW

SGLT-2 INHIBITOR EMPAGLIFLOZIN EFFECTS ON APPETITE AND WEIGHT REGULATION: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

SENSE

Randomised, double blind, placebo- controlled trial of L-serine in Hereditary Sensory Neuropathy type 1

SepTIC

There are 3 SepTIC trials (imperial16, imperial17, imperial18)

SEPTUM

Study to Evaluate the Prevalence and Treatment of women with Uterine Malformation.

Severe asthma

A feasibility study to inform the development of a multicentre randomised controlled trial of an asthma-tailored pulmonary rehabilitation programme versus usual care for individuals with severe asthma.

SGA Metformin

Effect of insulin sensitization on insulin like growth factor-1 responses to growth hormone treatment in children born small for gestational age.

SHAPE

The Supervised home-based exercise program for Peripheral artery disease trial.

SHIPSS

First trial of enterprise subscription

SHORTER

A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis

SIGNET

Statins for Improving orGaN outcomE in Transplantation

SIMPLE

The Efficacy of Sonographic and Biological Pleurodesis Indicators of Malignant Pleural Effusion – a randomised trial

Simvastatin in sight threatening Uveitis trial

Published

Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial. A UCL trial funded by the Moulton Trust.

SINAPPS2

A randomised phase II double-blinded placebo-controlled trial of intravenous immunoglobulins and rituximab in patients with antibody-associated psychosis

SIP SMART 2

SIZOMUS

Safety of ixazomib targeting plasma cells in multiple sclerosis: A phase 1b randomised, double-blind, placebo-controlled trial

SKOAP

A Sequenced Strategy for Improving Outcomes in People with Knee Osteoarthritis Pain (SKOAP)

SLIM-CARD

Pre-operative weight management to improve outcomes of cardiac surgery in adults with obesity (SLIM-CARD): a multicentre feasibility RCT

Smart

Surgical and large bore pleural procedures in Malignant Pleural Mesothelioma And Radiotherapy Trial. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).

SMART-C

Simplified Monitoring - A Randomised Trial in hepatitis C

SMS study

Diabetes Prevention using SMS trial. A mobile phone intervention for lifestyle change in people with impaired glucose regulation (high risk at developing type 2 diabetes). Imperial College London.

SNAP

SNAP (Silicon Nitride and PEEK) Trial. A Clinical Study of the Amedica Corporation Interbody Fusion Devices for PLIF. The primary objective is to compare the average improvement in Roland Morris Disability Questionnaire for Valeo OL patients versus those that receive similarly-shaped PEEK cages.

SOFIE

Surgery for Olecranon Fractures in the Elderly: a randomised controlled trial of operative versus non-operative treatment

SOGAS

Omega–3 fatty acids for the prophylaxis of acute attacks of gout on initiating urate lowering treatment – feasibility study for a randomised controlled trial

SPECIFIC

Parenting course for parents of children with fetal alcohol spectrum disorders (FASD) versus waitlist: a randomised controlled feasibility study of the SPECIFIC (Salford Parents and carers’ Education Course for Improvements in Fasd outcomes In Children) Programme

SPIRIT

Studying Pleuroscopy In Routine Pleural Infection Treatment

SSCART

A double blind, placebo controlled, randomised dose escalation trial to investigate the safety and efficacy of topical salbutamol in the improvement of scar appearance when applied to approximated wound margins in healthy volunteers.

STAND UP

Sedentary behaviour in older adults: investigating a new therapeutic paradigm. Work Package 3: Investigating the effect of sedentary time, reduced sedentary time and increased light-intensity physical activity on metabolic and psychological health in older adults. University of Leicester.

STATIC

STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial

STATIN

RandomiSed conTrolled trial with prAvasTatin versus placebo for preventIoN of preeclampsia

STEEL PCI

Study of two regimens of TicagrElor compared to clopidogrel in patients undergoing ELective Percutaneous Coronary Intervention (STEEL PCI). Sheffield Teaching Hospitals NHS Foundation Trust.

STEMI Cool

STEMI Cool Trial: A Multicenter, Prospective, Randomized-Controlled Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction

STICK

Sodium InTake In Chronic Kidney Disease (STICK): A Randomised Controlled Trial

STIMULATE-ICP

A pragmatic, multi-centre, cluster-randomised trial of an integrated care pathway with a nested Phase III, open label, adaptive platform, randomised drug trial in individuals with Long COVID

STRATA

A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with a diagnosis of Autism

StratosPHere 2 Hap

A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2

StratosPHere 2 Miss

A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2

STRI12

Study to Reinforce Immunity (STRI) Phase 2 Clinical Trial

STRIPE

Randomised control trial of Tibial nerve stimulation in Parkinson’s disease

STRIVE

Effectiveness and cost of integrating a protocol with use of liraglutide 3.0 mg into an obesity service

SWEET

A Randomized Controlled Trial Evaluating the Safety and Effectiveness of the AI- Driven Signos System for Personalized Weight Management in Overweight and Obese Adults

SWIFT

A Multi-Centre Randomised Controlled Trial of the Clinical and Cost-Effectiveness of Pre- Hospital Whole Blood Administration versus Standard Care for Traumatic Haemorrhage

T4P

The Threshold for Platelets (T4P) Study: A prospective randomised trial to define the platelet count below which critically ill patients should receive a platelet transfusion prior to an invasive procedure.

TACTIC

Telomerase ACTivator to reverse Immunosenescence in Acute Coronary Syndrome: a double-blind, phase II, pilot randomised controlled trial

TACTIC (Oxford)

The Randomised Thoracoscopic Talc Poudrage + Indwelling Pleural Catheters versus Thoracoscopic Talc Poudrage only in Malignant Pleural Effusion Tria

TACTIC-E

mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Experimental drugs and mechanisms

TACTIC-R

mulTiArm Therapeutic study in pre-Icu patients Admitted with Covid-19 – Repurposed drugs

TALGiTS

Trial of Alginates in Throat Symptoms

TANDEM

A randomised controlled Trial of high and low dose Avastin® for Neovascular macular Degeneration in the East Midlands.

TAPPS

Published

Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).

TAPS02

Targeted drug intervention in men at risk of progression on active surveillance for early prostate cancer: A randomised trial – Therapeutics in Active Prostate cancer Surveillance (TAPS02)

TARVA

Published

Total Ankle Replacement Versus Arthrodesis Trial: A randomised, multi-centre, non-blinded, prospective, parallel group trial of total ankle replacement (TAR) versus ankle arthrodesis, comparing clinical outcomes and cost-effectiveness.

TEAL

TELE-DFD

Assessment of the impact of a TeleHealth Program for the control of modifiable risk factors in people at risk of Diabetes-related Foot Disease

TEMPLATE

A Randomised Controlled Trial Investigating the Pharmacodynamic Effect of Ticagrelor Monotherapy on Platelet Reactivity in Patients with Coronary Artery Disease: The TEMPLATE Study

TEPHRA

Trial of Exercise To Prevent Hypertension in Young Adults

The Altitude Registry

Multi-centre, Observational, Post-Market, Real World Registry to assess Outcomes of Patients Treated with the Altura Endograft System for Endovascular Abdominal Aortic Aneurysm Repair

THRIVE-ON

A randomised controlled comparison of effectiveness of facemask preoxygenation and Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) in bariatric patients undergoing general anaesthesia.

TICONC

Published

Investigating Aspirin and Ticagrelor for the prevention of Tumour cell-induced platelet aggregation

TIGER

Tight K (main trial)

The Tight K Trial. Prevention of dysrhythmias on the cardiac intensive care unit - does maintenance of high-normal serum potassium levels matter?

Tight K Pilot

PILOT STUDY for the Tight K TRIAL. Arrhythmias on the cardiac intensive care unit - does maintenance of high-normal serum potassium levels matter?

TIHM for dementia

Technology Integrated Health Management for dementia

TIPS

First-in-human open label feasibility study to assess the safety of TIPS microspheres in perianal fistulas

TITRE

TLT_018

A Randomized Cross-over Study to Evaluate Local Tolerability Following Subcutaneous Administration of TV-46046

TOP HAT

Trial of Ondansetron as a Parkinson’s HAllucinations Treatment

ToSCA

Trial of Sertraline versus Cognitive behavioural therapy in generalised Anxiety

TOXYC

A randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients. (A feasibility study)

Tractiss

Code break application for a randomized double blind placebo controlled clinical trial of anti-b-cell therapy in patients with primary Sjögren’s Syndrome.

TRAK-ER

A randomised trial of early detection of molecular relapse with circulating tumour DNA tracking and treatment with palbociclib plus fulvestrant versus standard endocrine therapy in patients with ER positive HER2 negative breast cancer

TransEUro

An Open Label Study to Assess the Safety and Efficacy of Neural Allo-Transplantation with Fetal Ventral Mesencephalic Tissue in Patients with Parkinson's disease. A trial coordinated by the Cambridge Centre for Brain Repair.

TRAPIST

Twin Reversed Arterial Perfusion Intervention STudy

Trauma-AID

Eye movement desensitisation and reprocessing for symptoms of post-traumatic stress disorder in adults with intellectual disabilities

Trauma-INTACT

Published

Pharmacokinetics of intramuscular tranexamic acid in trauma patients: a clinical trial (Acronym: Trauma-INTACT)

TREAT

Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab

TREAT CASP

The Evaluation of blood pressure treatment stratified according to Central Aortic Systolic Pressure (CASP) in Young Hypertensive Patients

TREATT

TRial to EvaluaAte Tranexamic acid in Thrombocytopenia.

TRED

A randomised controlled pilot trial of the feasibility and safety of therapy withdrawal in asymptomatic patients with a prior diagnosis of dilated cardiomyopathy and recovered cardiac function

TRED-HF2

Triclosan sutures

Published

A randomised controlled trial of Polyglactin 910 Triclosan coated sutures versus standard Polyglactin 910 sutures in patients aged 18 or over undergoing primary unilateral hip and knee arthroplasty in the Department of Trauma and Orthopaedics at University College London Hospital

Trimetazidine in HCM

Published

A Phase 2b randomised, double blind, placebo-controlled trial of trimetazidine therapy in patients with non-obstructive hypertrophic cardiomyopathy (HCM). The sponsor is University College London (UCL).

Trioc

A Randomised Parallel Group Double-Blind Phase II Study to Assess the Activity of TroVax® (MVA-5T4) Versus Placebo in Patients with Relapsed Asymptomatic Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

TRuSST

Treatment of Social Cognition in Schizophrenia Trial.

txt4safersex

Published

Can text messages increase safer sexual health behaviours in young people? Pilot Trial

UK Mini Mitral

Conventional versus minimally invasive mitral valve repair for version 2

UK-ROX

Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy (UK-ROX).

UPB-CP-01

UPDATE

UPDATE (Crossover diet trial Diet A then Diet B or Diet B then Diet A)

USTEKID

Phase II Multi-centre, double-blind, randomized trial of Ustekinumab in adolescents with new-onset type 1 diabetes

VA02

Impact of guided care with the Vectra DA multi-biomarker disease activity (MBDA) blood test on clinical outcomes and pharmaceutical utilization in patients with rheumatoid arthritis: A prospective, randomized study

VAC088

A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children

VAC088 Group 4

A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children

VAC088 Group 5

VAC088 Group 6

A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children

Val-CARD

A randomised controlled trial of Pre-surgery Sodium ValpRoate, for the prevention of organ injury in cardiac surgery: THE Val-CARD TRIAL

VALID

Valuing Active Life in Dementia

VDORA1

Vitamin D Supplementation in Children With Obesity-Related Asthma (VDORA1)

VeRDiCT

Published

Preoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery, a randomised controlled Trial.

VIBMOR

Whole Body Vibration

Viiv DOL

The effect of dolutegravir on whole-body insulin sensitivity, lipid and endocrine profile in healthy volunteers

ViKTORIES

Vitamin K in kidney Transplant Organ Recipients: Investigating vEssel Stiffness

Vinehealth

Multi-centre, randomised controlled trial of Vinehealth® digital health cancer solution for cancer patients commencing chemotherapy

Violet

VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot

VIP

The VIP trial: a randomised controlled trial of the clinical and cost effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime.

VOCALIST

Does Laryngeal Reinnervation or Type I Thyroplasty give better voice results for patients with Unilateral Vocal Fold Paralysis (VOCALIST): a feasibility study

VOT vs DOT

Individually randomised controlled trial comparing clinic led face-to-face treatment observation (DOT) versus virtually observed treatment (VOT) organised by TB Reach study team to inform optimal treatment delivery.

War Fighter 3

Weight Loss

WISARD

An open-label, multi-centre, randomised, switch study to evaluate the virological efficacy over 96 weeks of 2-drug therapy with DTG/RPV FDC in antiretroviral treatment-experienced HIV-1 infected subjects virologically suppressed with NNRTIS resistance mutation K103N

WOB

WOBE-SMART

Woman

Published

Tranexamic Acid for the Treatment of Postpartum Haemorrhage: an international Randomised, Double Blind, Placebo Controlled Trial.

Woundchek

WOUNDCHEK Protease Status Point of Care (POC) Diagnostic Test. A Prospective, Multi Centre, Randomised, Clinical Study on Venous Leg Ulcers and Diabetic Foot Ulcers.

WP3

Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients. Imperial College.

WP4

Targeted retreatment of incompletely recovered COPD exacerbations with ciprofloxacin: a double-blind, randomised, placebo-controlled, multicentre Phase III trial. Imperial College.

WYSA

Real world testing of an artificial intelligence- enabled app as an early intervention and support tool in the mental health referral care pathway

YORKSURe

Early detection of bladder cancer in Yorkshire: Feasibility assessments for implementing a targeted study in populations with high disease specific mortality risk

Young with diabetes

A multicenter randomized controlled trial testing the app 'Young with Diabetes'

Zol-A

Zol-A Trial eligibility

Zoledronic Acid Trial

Published

A double blind randomised controlled trial examining the effect of intravenous zoledronic acid on pleural tumour progression, pleural fluid production, breathlessness and quality of life in patients with malignant pleural disease.


Prognostic models

Crash 2 model

Prognostic model for predicting outcome after traumatic brain injury

BWHHS Prognostic model for incident locomotor disability in older adults

A prognostic model that may be used as an aid to estimate the risk of incident locomotor disability within 7 years. Developed from data collected in the British Women's Heart and Health Study.

PISA model (Prognosis In Suspected Angina)

A prognostic model that may be used as an aid to estimate the risk of coronary and cardiovascular death in patients with suspected angina.