This is a list of trials which are using or have used Red Pill or our comprehensive randomisation service. Hundreds more trials have also been set-up on our popular simple randomisation service.
A prospective, randomised, placebo-controlled double blind, multi-centre study of the effects of Irbesartan on aortic dilatation in Marfan syndrome.
Platelets for Neonatal Transfusion (PlaNeT) study 2. A trial to compare two platelet transfusion thresholds, and establish whether a lower platelet transfusion threshold is as safe as a higher threshold.
A randomized trial of Rituximab in induction therapy for living donor renal transplantation. This is a Phase IV randomised, open label, controlled trial.
Maraviroc in HIV Post Exposure Prophylaxis (MiPEP) Trial. Randomised controlled trial of the tolerability and completion of maraviroc compared to Kaletra in combination with Truvada for HIV post-exposure prophylaxis.
Health-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy.
Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
Randomised controlled trial of the clinical and cost-effectiveness of a contingency management intervention for reduction of cannabis use and of relapse in early psychosis.
Enrolment of patients to a Prospective Multicentre Clinical Surveillance Study To Evaluate The Stability, Efficacy And Safety Of The Furlong Evolution® Hip Stem In Primary Total Hip Arthroplasty.
The second European Carotid Surgery Trial. ECST-2 (ISRCTN 97744893) is an international randomised trial comparing the treatment of mild to moderate carotid stenosis by optimized medical management alone with carotid surgery or stenting and optimized modern medical management.
POWAR Study (Prophylaxis Of Wound infections - Antibiotics in Renal donation). Are prophylactic antibiotics necessary before laparoscopic living kidney donation? A double blind, randomised, controlled trial.
A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia plus Magnesium Sulphate (MgSO4) vs. Therapeutic Hypothermia plus Placebo in the management of Term babies with Hypoxic Ischemic Encephalopathy. Hamad Medical Corporation.
A comprehensive comparison of the sensitivity of common exercise outcome measures for Chronic Obstructive Pulmonary Disease (COPD).
Gastric BYpass or adjustable gastric BANDing surgery or Sleeve Gastrectomy surgery to treat morbid obesity: a multi-centre randomised controlled trial.
A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery.
A Randomised Parallel Group Double-Blind Phase II Study to Assess the Activity of TroVax® (MVA-5T4) Versus Placebo in Patients with Relapsed Asymptomatic Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Revascularisation for Ischaemic Ventricular Dysfunction - a multicentre prospective randomised open controlled trial. The aim is to evaluate the efficacy and safety of percutaneous coronary intervention compared to optimal medical therapy alone for ischaemic left ventricular dysfunction.
Understanding the importance of plasticity in the brain mechanisms of dyspnoea perception
An Open Label Study to Assess the Safety and Efficacy of Neural Allo-Transplantation with Fetal Ventral Mesencephalic Tissue in Patients with Parkinson's disease. A trial coordinated by the Cambridge Centre for Brain Repair.
An Investigation into the efficacy of Mirococept (APT070) for preventing ischaemia-reperfusion injury in the kidney allograft (EMPIRIKAL). King's College London and Guy's & St Thomas' NHS Foundation Trust.
Fluoxetine Or Control Under Supervision Poland. A randomised trial to establish the effect(s) of routine administration of Fluoxetine in patients with a recent stroke in Poland.
The effect of remote ischaemic preconditioning and glyceryl trinitrate on peri-operative myocardial injury in cardiac bypass surgery patients (ERIC-GTN study) - a four arm randomised, controlled trial.
Reducing pathology in Alzheimer's Disease through Angiotensin taRgeting. University of Bristol School of Social & Community Medicine
Remote ischaemic preconditioning for brain protection in paediatric cardiac surgery. This trial is run by UCL Institute of Cardiovascular Science & Great Ormond Street Hospital.
A multicentre, non-blinded, randomised controlled trial to assess the impact of Regular Early SPEcialist symptom Control Treatment on quality of life in malignant Mesothelioma – “RESPECT-Meso”
A phase IIa/b, randomised, double-blind, placebo-controlled, single-site, parallel group clinical trial to examine cannabidiol (CBD) as a pharmacological treatment for cannabis dependence in a young cannabis dependent population.
A multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly-controlled, severe allergic asthma.
Surgery for Olecranon Fractures in the Elderly: a randomised controlled trial of operative versus non-operative treatment
Hughes Abdominal Repair Trial
Human papillomavirus infection: a randomised controlled trial of Imiquimod cream (5%) versus Podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts.
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients. Imperial College.
Targeted retreatment of incompletely recovered COPD exacerbations with ciprofloxacin: a double-blind, randomised, placebo-controlled, multicentre Phase III trial. Imperial College.
Valuing Active Life in Dementia
A randomised controlled trial evaluating the efficacy of indwelling pleural catheters in persistent non-malignant symptomatic pleural effusions.
A Randomised Controlled Trial Assessing the Impact of a Low Calorie Diet on Weight Loss in Obese Patients with Type 2 Diabetes Mellitus Treated with Insulin.
How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Brighton & Sussex University Hospitals NHS Trust
Kidney Disease in Type 2 Diabetes Mellitus: Biomarker Discovery and Novel Therapeutics.
Total Ankle Replacement Versus Arthrodesis Trial: A randomised, multi-centre, non-blinded, prospective, parallel group trial of total ankle replacement (TAR) versus ankle arthrodesis, comparing clinical outcomes and cost-effectiveness.
Obstructive sleep apnoea and retinal vasculature reactivity
Effects of intravenous iron in COPD
A randomised phase II pilot study of 3 weekly Cabazitaxel versus weekly Paclitaxel chemotherapy in the first line treatment of HER2 negative breast cancer.
Treatment of Social Cognition in Schizophrenia Trial.
Ketogenic diet in infants with epilepsy (KIWE)
What are the indications for Prescribing ANtiDepressAnts that will lead to a clinical benefit? A Phase IV, double-blind randomised placebo-controlled, parallel group multi-site trial; of sertraline compared to placebo in patients presenting with depressive symptoms in primary care where treatment with SSRIs is uncertain.
Health-Related Quality of Life in two treatment pathways for newly diagnosed open angle glaucoma and ocular hypertension: an unmasked, multi-centre randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy
Individually randomised controlled trial comparing clinic led face-to-face treatment observation (DOT) versus virtually observed treatment (VOT) organised by TB Reach study team to inform optimal treatment delivery.
Comprehensive moUthcare to Prevent Postoperative pneumoniA
A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma. Papworth Hospital, Cambridge.
A Randomised Comparison of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.
TRial to EvaluaAte Tranexamic acid in Thrombocytopenia.
Acetic Acid guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomised tandem endoscopy trial. The ABBA study
A Prospective, Randomised Controlled Trial Comparing Glycaemic Benefits of Active Versus Passive Lifestyle Intervention in Kidney Allograft Recipients.
VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot
Hypothermia for Encephalopathy in Low and Middle-Income Countries (HELIX) trial
A Randomised Controlled Trial Investigating the Pharmacodynamic Effect of Ticagrelor Monotherapy on Platelet Reactivity in Patients with Coronary Artery Disease: The TEMPLATE Study
Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial. A UCL trial funded by the Moulton Trust.
Study to Evaluate the Prevalence and Treatment of women with Uterine Malformation.
Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI): A multicentre randomised controlled clinical trial
Morphine for the relief of breathlessness in heart failure.
Colchicine in Patients with Acute Coronary Syndromes
Albumin To prevenT Infection in chronic liveR failurE
The Efficacy of Sonographic and Biological Pleurodesis Indicators of Malignant Pleural Effusion – a randomised trial
Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular dysfunction
A Randomised controlled, open label trial of Ex-vivo Normothermic Perfusion versus Static Cold Storage in Donation after Circulatory Death Renal Transplantation
Improving Outcomes in Fistula Intervention: A prospective, patient blinded, phase 3, randomised controlled trial of Drug Eluting Balloons in the Angioplasty of Native Haemodialysis Access Arteriovenous Fistula Outflow Stenosis
A comparison of Glycosade® and Uncooked Cornstarch (UCCS) for the dietary management of hepatic glycogen storage diseases (GSD
POMS2b: Prevention of Morbidity in Sickle Cell Disease (Phase II)
Attention Training for Learning Enhancement and Resilience Trial
The Effect of Sildenafil (REVATIO®) on Post Cardiac Surgery Acute Kidney Injury (AKI): A Randomised, Placebo-controlled Clinical Trial.
A randomised controlled pilot trial of the feasibility and safety of therapy withdrawal in asymptomatic patients with a prior diagnosis of dilated cardiomyopathy and recovered cardiac function
Twin Reversed Arterial Perfusion Intervention STudy
Hypothermia as an adjunctive therapy to percutaneous coronary intervention in patients with acute myocardial infarction.
Aggression Following Traumatic Brain Injury (TBI): Effectiveness of Risperidone – a Feasibility RCT
Partner: Platinum & Parp-Inhibitor for neo-adjuvant treatment of Triple Negative and/or BRCA Positive Breast Cancer
Trial of Exercise To Prevent Hypertension in Young Adults
Clinical trial examining the effect of ketamine in combination with CBT on relapse rate in alcoholics.
Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis.
A Randomised Controlled Trial for People with Established Type 2 Diabetes during Ramadan: Canagliflozin (Invokana™) vs. standard dual therapy regimen.
RandomiSed conTrolled trial with prAvasTatin versus placebo for preventIoN of preeclampsia
Investigating Aspirin and Ticagrelor for the prevention of Tumour cell-induced platelet aggregation
Conventional versus minimally invasive mitral valve repair for version 2
Diabetes Mobile Monitoring and Management Advantage Study
Corneal cross-linking versus standard care in children with keratoconus; a randomised, multicentre, observer-masked trial of efficacy and safety
pRotective vEntilation with veno-venouS lung assisT in respiratory failure
Cambridge Brain Mets Trial 1
Prevention Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction
Zol-A Trial eligibility
Safety and efficacy of Belimumab After B cell depleTion therapy in systemic LUPUS erythematosus
Investigating the effects of a prebiotic supplement on learning and behaviour in children from academic year groups 3, 4 and 5, whose reading scores suggest there is room for improvement: a randomised placebo-controlled study. University of Oxford.
SGLT-2 INHIBITOR EMPAGLIFLOZIN EFFECTS ON APPETITE AND WEIGHT REGULATION: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
A randomised study of interferon-free treatment for recently acquired hepatitis C in people who inject drugs and people with HIV coinfection (REACT)
COlchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke – a randomised clinical trial of low-dose colchicine for secondary prevention after stroke
Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury
Randomised, multi-centre study to assess efficacy, tolerability and safety of Enterosgel® in treatment of acute diarrhoea in adults
DIAbetic Macular Oedema aNd Diode Subthreshold micropulse laser
Does Laryngeal Reinnervation or Type I Thyroplasty give better voice results for patients with Unilateral Vocal Fold Paralysis (VOCALIST): a feasibility study
A multicentre randomised controlled trial to evaluate the effect of Heimlich valves on length of stay in patients admitted to hospital with secondary spontaneous pneumothorax.
ComparIsoN oF Optimal Hypertension RegiMens (Part of the Ancestry Informative Markers in Hypertension (AIM HY)
Randomized Controlled Trial to evaluate the effectiveness of an intervention using mobile technology for the treatment of depressive symptoms in people with diabetes and/or hypertension
OFORT003 - Lyophilized Amniotic Fluid
Randomised controlled trial comparing the diagnostic yield of Radial Endo-Bronchial Ultra-Sound (R-EBUS) guided Cryo-biopsy Vs. CT guided transthoracic biopsy in patients with parenchymal lung lesion.
Technology Integrated Health Management for dementia
ANTidepressants to prevent reLapse in dEpRession
Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial assessing the impact of low calorie diet and activity on body weight and glycaemia in diabetes in early diabetes
A Randomised Pilot Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children
Sodium InTake In Chronic Kidney Disease (STICK): A Randomised Controlled Trial
Increasing uptake and adherence to long-acting reversible contraceptive (LARC) methods in young women
Iron and Chronic Obstructive Pulmonary Disease COPD Exercise Trial. To test the hypothesis that intravenous iron improves exercise performance in COPD as measured by constant rate cycle ergometry.
Multicenter, prospective, randomized-controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction
A Randomised Placebo Controlled Trial of the effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects
Research into Antipsychotic Discontinuation and Reduction
A phase III multicentre randomised controlled trial to compare the efficacy of Robotically Assisted Radical Cystectomy and intracorporeal urinary diversion with Open Radical Cystectomy in patients with bladder cancer.
Insulin degludec titration using mobile insulin dosing system
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients.
A Randomized Trial to confirm the Safety and Effectiveness of Chocolate Touch™ Paclitaxel Coated PTA Balloon Catheter, in Above the Knee Lesions
A randomised phase II double-blinded placebo-controlled trial of intravenous immunoglobulins and rituximab in patients with antibody-associated psychosis
Supporting adults with Type 1 Diabetes (T1DM) to undertake exercise; Developing and piloting an Education programme for exercise in Type 1 diabetes: EXercise for Type 1 Diabetes (EXTOD) education
A pilot clinical trial and feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a Phase III trial
Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer
PILOT STUDY for the Tight K TRIAL. Arrhythmias on the cardiac intensive care unit - does maintenance of high-normal serum potassium levels matter?
Simplified Monitoring - A Randomised Trial in hepatitis C
Preventing cardiac damage in patients treated for breast cancer and lymphoma: a phase 3 Randomised, Open label, blinded endpoint, superiority trial of enalapril to prevent Anthracycline-induced CardioToxicity
Vitamin K in kidney Transplant Organ Recipients: Investigating vEssel Stiffness
Interactions between the diet and gut microbes, metabolism and body composition in preterm infants
A randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients. (A feasibility study)
A multi-centre, pilot, randomised clinical trial of a more permissive temperature threshold for antipyretic intervention in critically ill children with known or suspected infection
Studying Pleuroscopy In Routine Pleural Infection Treatment
Effect of insulin sensitization on insulin like growth factor-1 responses to growth hormone treatment in children born small for gestational age.
DIrect or Subacute COronary angiography in out-of-hospital cardiac arrest – a prospective, randomized study
STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial
160382 Dr Reddy's - Oral DFD-29 for the Treatment of Rosacea
Tranexamic acid for the treatment of significant traumatic brain injury: an international randomised, double blind placebo controlled trial
Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): A randomised controlled trial
Pain Reduction with Oral Methotrexate in knee Osteoarthritis, a pragmatic phase III trial of Treatment Effectiveness
INTERIM: a randomised phase II feasibility study of INTERmittent versus continuous dosing of oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma
Evaluation of Parent Intervention for Challenging Behaviour in Children with Intellectual Disabilities
AmnioFix for Plantar Fasciitis, Phase III IND
Code break application for the Symptomatic versus Antibiotic Treatment of urinary tract INfection trial.
The VIP trial: a randomised controlled trial of the clinical and cost effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime.
Acetabular Fractures in older patients Intervention Trial. A feasibility study comparing three methods of treatment of acetabular fractures in older patients; surgical fixation versus surgical fixation and hip replacement versus non-surgical treatment
Effectiveness and cost of integrating a protocol with use of liraglutide 3.0 mg into an obesity service
A phase II, open label, non-randomised, single centre, clinical trial of ANX776 in healthy volunteers and patients with Glaucoma, Age-Related Macular Degeneration and Optic Neuritis
The Prognosis in Palliative care Study II (PiPS2): A multicentre prospective, observational, validation cohort study.
Smoking Cessation for Severe Mental Ill Health Trial
PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr trial
AmnioFix for Achilles Tendonitis, Phase III IND
A feasibility study of the use of Betashot, a medium chain triglyceride-based (MCT) food for special medical purposes (FSMP) in children and adults with epilepsy.
A double blind, placebo controlled, randomised dose escalation trial to investigate the safety and efficacy of topical salbutamol in the improvement of scar appearance when applied to approximated wound margins in healthy volunteers.
A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out-of-hospital cardiac arrest (ARREST)
Reducing perioperative risk in chronic obstructive pulmonary disease with pre-operative pulmonary rehabilitation
Implementation of COPD Case Finding and Self-Management Action Plans in Low and Middle Income Countries
Multi-centre, Observational, Post-Market, Real World Registry to assess Outcomes of Patients Treated with the Altura Endograft System for Endovascular Abdominal Aortic Aneurysm Repair
A 2x2 factorial randomised examiner blind open label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in bronchiectasis
Depletion of Serum Amyloid P Component In Alzheimer’s Disease
A phase II randomised placebo controlled double blinded trial of Interleukin 1 blockade in Acute Severe Colitis
Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial
A Randomised Controlled Trial to test novel invitation methods and materials targeted to increase INFORMED uptake of lung cancer screening in individuals at high risk of lung cancer.
Pilot cluster randomised trial of an evidence based intervention to reduce avoidable hospital admissions in residents in care homes (the Better Health in Residents in Care Homes study)
A randomized, controlled trial of the use of a dedicated ballooned intercostal drain
The Glooko Diabetes Mobile Monitoring and Management Advantage Study (GL1v3)
AmnioFix Injectable in the Treatment of Knee Osteoarthritis, Phase 2B
A randomized controlled trial of remedial after-school support classes in rural Gambia
Algorithmic Protamine Dosing for Reversal of Heparin after Cardiopulmonary Bypass (PRODOSE)
Promoting home-based walking exercise using telephone-based health coaching and activity monitoring for patients with peripheral artery disease (TeGeCoach)
A single blinded, multi-centre site, feasibility study to evaluate the ability to randomise men with prostate cancer into a trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard Robotic assisted radical prostatectomy (RALP)
A phase 3 randomised, double blind, clinical trial investigating the effectiveness of repurposed simvastatin compared to placebo, in secondary progressive multiple sclerosis, in slowing the progression of disability
Conventional versus Minimally Invasive extra-corporeal circulation in patients undergoing Cardiac Surgery: a randomised controlled trial
Therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents with Tourette syndrome: an internal pilot study and single-blind randomised controlled trial
The Benefit Of Night splinting in Dupuytrens
Methylphenidate versus placebo for fatigue in advanced cancer
Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local breast cancer recurrence? A randomised controlled feasibility study.
Feeding in Late and Moderately Preterm Infants and Growth Outcomes
BT-LIFE, Brain Tumours, Lifestyle Interventions and Fatigue
Managing Agitation and Raising Quality of Life: feasibility trial of an intervention to improve the management of agitation in severe dementia
A randomised controlled comparison of effectiveness of facemask preoxygenation and Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) in bariatric patients undergoing general anaesthesia.
Cooling in Mild Encephalopathy Trial (COMET) – Feasibility study
Dapagliflozin during exercise for the prevention of Hypoglycaemia in Type 1 diabetes – Pilot study
A psychological intervention for suicide applied to patients with psychosis: The CARMS trial (Cognitive Approaches to Combatting Suicidality).
A double-blinded, randomised, placebo-controlled trial of liraglutide 3.0 mg in patients with poor weight-loss and a suboptimal glucagon-like peptide-1 response following bariatric surgery.
A randomised controlled trial of very early versus delayed angiography +/-Intervention on outcomes in patients with non ST-elevation myocardial infarction
IL-6 Inhibition in Patients with Depression and Low-grade Inflammation: The Insight Study
The ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) Randomised Controlled, Feasibility in Older People) Trial
Efficacy and tolerability of NL-01, a food ingredient, in older adults at risk of Acute Respiratory Tract Infections (ARTI) during the winter season
A randomised placebo-controlled trial of anti-ST2 in COPD (COPDST₂OP)
A Randomized Cross-over Study to Evaluate Local Tolerability Following Subcutaneous Administration of TV-46046
Phase II Multi-centre, double-blind, randomized trial of Ustekinumab in adolescents with new-onset type 1 diabetes
Whole Body Vibration
Clinical and cost evaluation of intensive support teams (IST) for adults with intellectual disabilities and challenging behaviour
KAI Research, Inc.
Comparison of Early Fusion in Anterior Cervical Decompression and Fusion (ACDF) with OsteoStrand™ Demineralized Bone Fibres and Cambria™ NanoMetalene® Implant Compared to Cabmria Uncoated Implant
Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel® in the treatment of Irritable Bowel Syndrome with Diarrhoea (IBS-D) in adults (RELIEVE IBS-D)
Managing Repetitive Behaviours: A clinical and cost effectiveness trial of a parent group intervention to manage restricted and repetitive behaviours in young children with Autism Spectrum Disorder
An open-label, multi-centre, randomised, switch study to evaluate the virological efficacy over 96 weeks of 2-drug therapy with DTG/RPV FDC in antiretroviral treatment-experienced HIV-1 infected subjects virologically suppressed with NNRTIS resistance mutation K103N
A randomised controlled trial of Pre-surgery Sodium ValpRoate, for the prevention of organ injury in cardiac surgery: THE Val-CARD TRIAL
Pro-active fecal calprotectin monitoring to improve patient outcomes in ulcerative colitis: a prospective randomised control trial
A randomised feasibility study of specialist physiotherapy for functional motor disorder
Weight Loss in Elderly Patients with Atrial Fibrillation (LOSE-AF): A Randomised Controlled Study
A randomised, double blind, controlled mechanistic study of rituximab and belimumab combination therapy in PR3 ANCA-associated vasculitis
Impact of guided care with the Vectra DA multi-biomarker disease activity (MBDA) blood test on clinical outcomes and pharmaceutical utilization in patients with rheumatoid arthritis: A prospective, randomized study
BiOmarkers in Urine, anTihypeRtensive trEAtment and blood pressure Control in Hypertensive patients
Vitamin D Supplementation in Children With Obesity-Related Asthma (VDORA1)
A Phase II, multicentre, randomised, placebo-controlled, double-masked trial of RP101 ophthalmic formulation versus vehicle in post-menopausal women with moderate to severe dry eye syndrome
Telomerase ACTivator to reverse Immunosenescence in Acute Coronary Syndrome: a double-blind, phase II, pilot randomised controlled trial
A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease
Randomised double-blind controlled trial of connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant moderate to severe depression: evaluation of efficacy, cost effectiveness and mechanism of action
PeRcutaneous cOronary intervention of native Coronary arTery versus venous bypass graft in patients with prior cORonary artery bypass graft surgery - the PROCTOR trial
A randomized controlled trial of red cell rejuvenation for the attenuation of transfusion associated organ injury in cardiac surgery: the REDJUVENATE trial
A pilot randomised controlled trial of one to one befriending by volunteers, compared to Usual Care, in reducing symptoms of depression in people with intellectual disability (ID)
A multicenter, prospective, randomized and subject blinded comparative study of AxoGuard Nerve Cap and Neurectomy for the Treatment of Symptomatic Neuroma and Prevention fo Recurrent End-Neuroma Pain
SIMVASTATIN IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS - A double-blind, randomised, placebo-controlled multi-site study of high dose simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage
A randomised controlled trial of pre-operative high energy diet for the prevention of organ injury in cardiac surgery: The PRE-OP ENERGY Trial
A randomised controlled trial to investigate the effect of structured education on people at high risk of cardiovascular disease" where name like '3R (Ready to Reduce Risk) study
Acupuncture treatment with threatened miscarriage: an exploratory study. Trial being conducted by the Centre for Complementary Medicine Research, University of Western Sydney.
Auto-inflation in children with otitis media with effusion (AIRS). A multi-centre trial being run by the Primary Care Clinical Trials Unit at the University of Oxford.
Evaluating the benefit of Additional Platelet inhibition in Acute Coronary Syndrome patients with high platelet reactivity undergoing PCI. A Randomised comparison of prasugrel versus clopidogrel re-loading in patients with ACS undergoing urgent PCI with persistent high platelet reactivity.
Combined multi-marker screening and randomised patient treatment with aspirin for evidence-based pre-eclampsia prevention.
A randomised phase II study to seek evidence that the addition of a potent src-inhibitor, AZD0530, to conventional aromatase inhibition, delays the onset of endocrine resistance in post- menopausal women with advanced breast cancer.
Use of Endothelin-1 antagonists in patients with established pulmonary hypertension and fibrotic lung disease - a randomised, placebo controlled, double-blinded study.
Ballon-pump Coronary Intervention Study.
BRAVE Trial. Broad-spectrum Cognitive Remediation Available to Veterans: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury (mTBI). Posit Science.
BRIDE (Barrett's Randomised Intervention for Dysplasia by Endoscopy) - a feasibility study
Low-dose atropine eye drops to reduce progression of myopia in children: a multi- centre placebo controlled randomised trial in the United Kingdom, (CHAMP UK)
Congestive Heart failure Cardiopoietic Regenerative Therapy (CHART-1) trial. Efficacy and Safety of Bone Marrow-Derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the treatment of chronic advanced ischemic Heart Failure. Cardio3 BioSciences SA.
A Multicenter, Prospective, Randomized Controlled Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction
Innovative use of antibiotics in the prevention of exacerbations of chronic obstructive pulmonary disease (COPD).
CORE Phase 3. A randomised controlled trial of a peer-provided self-management intervention for people leaving CRT care.
A randomised phase II study evaluating cediranib vs. cediranib and saracatanib in patients with relapsed metastatic clear cell renal cancer.
Microbleeds and genetic risk factors to predict the risk of intracranial haemorrhage in patients treated with anticoagulation following cardioembolic stroke due to atrial fibrillation.
Complete Versus Lesion-only PRimary PCI PiloT Study. Prospective observational registry and open multi-centre randomised controlled trial (RCT) in a subset of patients with multi-vessel coronary artery disease.
A phase III, open, randomised, multi-site trial to assess the clinical and cost-effectiveness of early parenteral, compared with early enteral, nutritional support in critically ill patients.
CanTalk: the clinical and cost effectiveness of CBT plus treatment as usual for the treatment of depression in advanced cancer; a randomised controlled trial.
The Coronary Artery Revascularisation in Diabetes (CARDia) trial
Cognitive behavioural therapy or medication for psychosis - a randomised evaluation.
A Phase I, Storer Design, open-label, cross-sectional, single site trial of ANX776 in healthy volunteers, progressive glaucoma/glaucoma-suspect/ocular hypertensive subjects and non-arteritic anterior ischaemic optic neuropathy subjects.
An Investigation to Evaluate an Over-The-Wire FFR Infusion Microcatheter (HYPEREM™IC) for Measuring Fractional Flow Reserve (FFR)
The DHA (docosahexaenoic acid) Oxford Learning and Behaviour (DOLAB II) Study. Does taking an Omega 3 food supplement help children’s learning and behaviour?
Direct Angioplasty for Non ST-Elevation Acute Coronary Events (DANCE Pilot Study). The aim of the DANCE pilot study is to compare an immediate versus delayed revascularisation strategy in high risk patients with non ST elevation Myocardial Infarction (NSTEMI).
DyeVert TP-6495 trial. Mobius Medical Pty Ltd, Australia
A feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the community
Effect of Remote Ischaemic preConditioning on clinical outcomes in patients undergoing Coronary Artery Bypass Graft surgery. A multicentre randomised controlled clinical trial to determine whether remote ischaemic preconditioning (RIC) improves clinical outcomes after cardiac surgery.
A randomised, double blind, placebo controlled, single centre, 60 week, trial of Exenatide for the treatment of moderate severity Parkinson's disease.
Randomised Feasibility Study of a Physiotherapy Programme for Patients with Functional Motor Symptoms (FMS).
Finding the optimal cooling tempeRature after Out-of-hoSpiTal cardiac arrest. Zoll Circulation Inc.
Using Real-Time Functional Brain Imaging to Enhance Recovery from TBI. The Geneva Foundation.
Globifer Forte® Oral Haem and Non-haem Iron Supplementation in Heart Failure
HEAL trial - Hepatic Encephalopathy And LOLA. Efficacy of intravenous 'L-ornithine L-aspartate' in reversal of overt acute hepatic encephalopathy in patients with liver cirrhosis: a prospective, randomized, double-blind, placebo controlled trial.
A randomised double-blind, placebo-controlled phase I/IIa trial to investigate the effect of depletion of serum amyloid P component (SAP) on the immune response to DNA vaccination in healthy male volunteers.
Randomised controlled trial of hospital at home directed by the DECAF score versus standard inpatient care for patients admitted with an acute exacerbation of COPD and embedded health economic and qualitative studies.
Randomised controlled trial of a web-based self management programme (HeLP-Diabetes) for people with type 2 diabetes in primary care.
HalOPeridol Effectiveness trial. A randomised, double-blind, placebo-controlled trial to compare the early administration of intravenous haloperidol versus placebo in the prevention and treatment of delirium in critically ill ventilated patients.
ICONS II - Identifying Continence OptioNs after Stroke randomized controlled trial
A proof of concept clinical trial investigating the effects of IL-1ra upon markers of inflammation in patients with Non-ST elevation myocardial infarction.
The efficacy of Indwelling Pleural Catheter placement versus IPC placement PLUS sclerosant (talc) in patients with malignant pleural effusions managed exclusively as out-patients.
Improving Mood with Psychoanalytic And Cognitive Therapies. Trial of Specialist Clinical Care (SCC) vs. Cognitive Behavioural Therapy (CBT) vs. Short Term Psychoanalytical Psychotherapy (STTP).
The Immediate Management of the Patient with Ruptured Aneurysm: Open Versus Endovascular repair. Imperial College, London.
Investigating the effect of post-operative home jejunostomy tube feeding on quality of life and nutritional parameters in patients with oesophago-gastric cancer: A pilot study
The aim of this study is to determine the efficacy of a novel therapy in the treatment for anorexia nervosa (AN), namely the Loughborough Eating disorders Activity theraPy (LEAP). LEAP is an innovative therapy that addresses the role of extreme exercise in the maintenance of AN using cognitive techniques and behavioural experiments and is fully integrated with an established manualised cognitive behavioural therapy for AN (mCBT-AN).
Impact of Liraglutide on cardiac function and structure in young adults with type 2 diabetes: an open-label, randomised active-comparator trial.
Treating neovascular age-related Macular degeneration with Aflibercept: a pilot 24 month, multi-centre randomised controlled trial comparing Standard Care with an individualised Treat and Extend regimen.
MINeralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-Elevation Myocardial Infarction (STEMI).
A randomized controlled trial of M.I.P.O. vs Intramedullary Nailing in fractured Tibias. The trial is being carried out at the Department of Surgery, King Abdul Aziz Medical City & King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Randomized Controlled Trial Comparing Intracoronary Administration of Adenosine or Sodium Nitroprusside to Control for Attenuation of Microvascular Obstruction During Primary Percutaneous Coronary Intervention.
The TB Reach MXU Peer Study. A cluster randomised controlled trial evaluating the impact of peer educators on uptake of MXU screening for TB among homeless populations.
Amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised controlled trial of Nutritional Evaluation and Optimisation in Neonates.
New technologies and tools to nutrition research - the example of phenotypic flexibility. Department of Investigative Medicine, Imperial College.
OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial
A phase II double-blind, randomised, placebo controlled trial of neuroprotection with phenytoin in acute optic neuritis. Sponsored by UCL and funded by the National Multiple Sclerosis Society and the Multiple Sclerosis Society of Great Britain and Northern Ireland.
Evaluation of Positive Behaviour Support (PBS). Randomised controlled trial to evaluate the clinical and cost effectiveness of PBS following standardised training of staff in routine clinical practice in community intellectual disability services.
Problem-solving intervention for people who have been recently diagnosed as blind or partially-sighted. The primary aim of this trial is to determine whether blind and partially sighted people who undertake Problem-Solving Treatment (PST) demonstrate better psychological well-being, mobility and quality of life than those undergoing usual care (rehabilitation).
PREvention STrategies for Adolescents at Risk of diabetes - A pilot study across 5 European countries.
Prediction and management of cardiovascular risk for people with severe mental illnesses.
The PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for those with prediabetes (PROPELS) - randomised controlled trial in a diverse multi-ethnic community.
Effectiveness of a Mentalization-based therapeutic intervention for parents in conflict over their children: a randomised controlled trial. Coordinated by The Tavistock Centre for Couple Relationships (TCCR).
Evaluating web based information for prevention of depression in general practice: an exploratory randomised controlled trial.
A multi-centre, randomised controlled trial of the clinical and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock.
Platelet Responsiveness and Outcome from Platelet Transfusion. Does inherent variation in donor platelet function affect the clinical efficacy of apheresis platelets? A randomised double blind single centre trial.
Pulmonary protection with low frequency ventilation during cardiopulmonary bypass: a prospective randomised study.
A Randomised trial of Pulmonary Metastasectomy in Colorectal Cancer. This is a two-stage randomised feasibility study. Patients will be firstly registered for evaluation and if subsequently eligible, randomised to active monitoring versus active monitoring with pulmonary metastasectomy.
Rivaroxaban in Antiphospholipid Syndrome (RAPS) Trial (EudraCT 2012-002345-38).
A randomised controlled trial of red cell washing for the attenuation of transfusion associated organ injury in cardiac surgery.
The REJOIN study (REhabilitation for Job and Occupational INdependence) – a feasibility study of a randomised controlled trial to evaluate a vocational rehabilitation intervention for people with cancer.
RESPONSE: REmediation of SPatial NEglect Trial. Posit Science.
Rivaroxaban In Stroke patients with AntiPhospholipid Syndrome
Pilot study for a randomised controlled trial of home based reach to grasp training for people after stroke.
Randomised double blind placebo-controlled trial to determine if remote ischaemic preconditioning (RIPC) improves renal function after transplantation.
Retinopathy and OSA Trial. A randomised controlled trial of Continuous Positive Airway Pressure in patients with impaired vision due to diabetic retinopathy and concurrent Obstructive Sleep Apnoea. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
A double blind randomised controlled trial to determine whether IV administered Kineret® inhibits the central nervous system (CNS) inflammatory response in patients with SAH
A novel diagnostic screening procedure for antipsychotic-induced movement disorders.
Diabetes Prevention using SMS trial. A mobile phone intervention for lifestyle change in people with impaired glucose regulation (high risk at developing type 2 diabetes). Imperial College London.
SNAP (Silicon Nitride and PEEK) Trial. A Clinical Study of the Amedica Corporation Interbody Fusion Devices for PLIF. The primary objective is to compare the average improvement in Roland Morris Disability Questionnaire for Valeo OL patients versus those that receive similarly-shaped PEEK cages.
Sedentary behaviour in older adults: investigating a new therapeutic paradigm. Work Package 3: Investigating the effect of sedentary time, reduced sedentary time and increased light-intensity physical activity on metabolic and psychological health in older adults. University of Leicester.
Study of two regimens of TicagrElor compared to clopidogrel in patients undergoing ELective Percutaneous Coronary Intervention (STEEL PCI). Sheffield Teaching Hospitals NHS Foundation Trust.
A feasibility study to inform the development of a multicentre randomised controlled trial of an asthma-tailored pulmonary rehabilitation programme versus usual care for individuals with severe asthma.
Surgical and large bore pleural procedures in Malignant Pleural Mesothelioma And Radiotherapy Trial. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
A randomised controlled Trial of high and low dose Avastin® for Neovascular macular Degeneration in the East Midlands.
First-in-human open label feasibility study to assess the safety of TIPS microspheres in perianal fistulas
The Evaluation of blood pressure treatment stratified according to Central Aortic Systolic Pressure (CASP) in Young Hypertensive Patients
Trial of Sertraline versus Cognitive behavioural therapy in generalised Anxiety
Code break application for a randomized double blind placebo controlled clinical trial of anti-b-cell therapy in patients with primary Sjögren’s Syndrome.
A randomised controlled trial of Polyglactin 910 Triclosan coated sutures versus standard Polyglactin 910 sutures in patients aged 18 or over undergoing primary unilateral hip and knee arthroplasty in the Department of Trauma and Orthopaedics at University College London Hospital
A Phase 2b randomised, double blind, placebo-controlled trial of trimetazidine therapy in patients with non-obstructive hypertrophic cardiomyopathy (HCM). The sponsor is University College London (UCL).
Preoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery, a randomised controlled Trial.
Tranexamic Acid for the Treatment of Postpartum Haemorrhage: an international Randomised, Double Blind, Placebo Controlled Trial.
WOUNDCHEK Protease Status Point of Care (POC) Diagnostic Test. A Prospective, Multi Centre, Randomised, Clinical Study on Venous Leg Ulcers and Diabetic Foot Ulcers.
A multicenter randomized controlled trial testing the app 'Young with Diabetes'
A double blind randomised controlled trial examining the effect of intravenous zoledronic acid on pleural tumour progression, pleural fluid production, breathlessness and quality of life in patients with malignant pleural disease.
The feasibility of recruiting and undertaking a randomised controlled trial to help with coping using two talking interventions, ACT or a Talking Control for people receiving treatment to control their cancer symptoms.
Increase in colonic PRopionate as a method of prEVENTing weight gain in young adults
Can text messages increase safer sexual health behaviours in young people? Pilot Trial
Omega–3 fatty acids for the prophylaxis of acute attacks of gout on initiating urate lowering treatment – feasibility study for a randomised controlled trial
Randomised controlled trial of nasal decongestants versus placebo to prolong treatment free periods from continuous positive airway pressure therapy in mild to moderate obstructive sleep apnoea
A randomised, placebo-controlled, double-blind trial of the antidepressant efficacy of a novel CNS-penetrant P2X7 receptor antagonist, JNJ-54175446, in people with major depressive disorder, an incomplete response to monoaminergic antidepressant drugs, and a biomarker profile predictive of active P2X7 signalling
FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): A master protocol of two randomised trials to evaluate the non-inferiority of high flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in paediatric critical care
PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients: a Feasibility Study
REperfusion with Cooling in CerebraL Acute IscheMia II
Metformin for treating peripheral artery disease-related walking impairment
Compliance with a high energy content, low volume Oral Nutritional Supplement (ONS)
Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events
A Multi-site randomised controlled trial assessing the effectiveness of the Little Journey app at reducing peri-operative anxiety compared to standard care.
A randomised, double-blind, placebo controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression.
Mental Health Intervention for Children with Epilepsy
Qatar Diabetes Mobile Application Trial
Low-dose interleukin-2 for the reduction of vascular inflammation in Acute Coronary Syndromes
Problem Adaptation Therapy for individuals with mild to moderate dementia and depression
Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis (ASEPTIC)
Primary care evaluation of a novel disposable neuromuscular electrical stimulation treatment for urinary incontinence: A randomised controlled trial
Pharmacokinetics of intramuscular tranexamic acid in trauma patients: a clinical trial (Acronym: Trauma-INTACT)
Phase 2a two-site randomised controlled trial to determine safety of and adherence with a new ‘Binocularly Balanced Viewing’ treatment for unilateral amblyopia compared with standard treatment in children age 3-8 years
An open-label, multi-centre, randomised, parallel design study to assess the efficacy of flash glucose monitoring in adults with type 1 diabetes
Quality-Assured Follow-up of quiescent neovascular age -related maculaR dEgeneration by non-medical practitioners: a randomised controlled trial
Prehabilitation in Elective Patients undergoing cardiac Surgery
A Randomised Controlled Trial of Mepolizumab Initiated During Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD
Confirming the Mechanism of Motivational Interviewing Therapy after Stroke: a multi-centre randomised controlled trial
Cholinesterase inhibitors to prevent falls in Parkinson’s Disease: A multicentre, phase III, double blind, randomised control trial of the cholinesterase inhibitor, rivastigmine versus placebo to prevent falls in Parkinson’s disease
Two-armed, double blind, randomised, controlled trial with ursodeoxycholic acid (UDCA) versus placebo for the treatment of Gestational Diabetes Mellitus (GDM)
A feasibility investigating different interventions for the treatment of benign paroxysmal positional vertigo in acute traumatic brain injury patients
Safety of ixazomib targeting plasma cells in multiple sclerosis: A phase 1b randomised, double-blind, placebo-controlled trial
Azathioprine Immunosuppression and Disease Modification in Parkinson’s Disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial
A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis (EASY-AS)
Peri-Vascular adipose tissue inflammation Evaluated using coronary CT angiography (P-VECT Study)
Membrane Sweeping for Induction of Labour – The MILO Study
Biologics in refractory vasculitis (BIOVAS): A pragmatic, randomised, double-blind, placebo-controlled, modified-crossover trial of biologic therapy for refractory primary non-ANCA associated vasculitis in adults and children
A Randomised Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children
Antidepressants Trial in Parkinson's Disease (ADepT-PD)
PlasmaLyte Usage and kidney Transplant Outcomes in children
Clinical and cost-effectiveness of a New psychological intervention to support Independence in Dementia (NIDUS) for family carers and people living with dementia in their own homes: A randomised controlled trial
The effects of dietary nitrate supplementation on pregnancies complicated by chronic and new onset hypertension
A novel targeted treatment for reducing anxiety in joint hypermobility: a proof of concept study (ADAPT)
Comparison trial of open-tip pulsed needle biopsy and conventional core biopsy in axillary lymph nodes (COMPULSE)
A Randomised Double-Blinded Placebo- Controlled Trial to Assess the Efficacy and Safety of Scopolamine Compared to Placebo in Individuals with Bipolar Disorder who are Experiencing a Depressive Episode
STEMI Cool Trial: A Multicenter, Prospective, Randomized-Controlled Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction
Beyond Allergic Th2 Severe Asthma (BEAT-SA)
Beyond Allergic Th2 Severe Asthma (BEAT-SA)
CROWN CORONATION (COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION) is an innovative prophylaxis clinical trial in response to COVID-19. The trial will assess candidate interventions that either modify the host immune response or target SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) to prevent symptomatic COVID-19. CROWN CORONATION is designed as a platform trial, such that interventions or combinations of interventions can be added as arms to which participants will be randomised.
Efficacy and safety of novel treatment options for adults with COVID-19 pneumonia. A double-blinded, randomized, multi-stage, 6-armed placebo-controlled trial in the framework of an adaptive trial platform
Open, multicentre, randomized controlled trial of cardiac output-guided haemodynamic therapy compared to usual care in patients undergoing emergency bowel surgery
ChemoPROphyLaxIs For covId-19 infeCtion (the PROLIFIC trial)
Impact of anatomical bladder neck preservation on functional and oncologic outcomes after robotic-assisted laparoscopic radical Prostatectomy
mulTiArm Therapeutic study in pre-Icu patients Admitted with Covid-19 – Repurposed drugs
A PHASE III Study of Immunogenicity and Safety Evaluation of AdimFlu-S (QIS)
IRST100.47 - PROTECT
mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Experimental drugs and mechanisms
Low dose aspirin for the prevention of intrauterine growth restriction and preeclampsia in sickle cell pregnancy: a randomised controlled trial
A national (UK), multi-centre, randomised, double-blind, placebo-controlled (1:1) phase IIb efficacy trial with cost-utility analysis of oral cladribine (3.5mg/kg over two years) in people with advanced multiple sclerosis (EDSS 6.5-8.5).
Regeneration in Cervical Degenerative Myelopathy - a multi-centre, double-blind, randomised, placebo controlled trial assessing the efficacy of Ibudilast as an adjuvant treatment to decompressive surgery for degenerative cervical myelopathy
Multi-arm trial of Inflammatory Signal Inhibitors for COVID-19
Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Study: Effect of High-Flow Nasal Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial
Efficacy of BIC/F/TAF versus standard of care in the treatment of new HIV infection diagnoses in the context of ‘test and treat’
A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Efficacy of ARCR augmented with REGENETEN Bioinductive Implant System in Full-thickness Tears (large or massive) Repair versus ARCR alone
A single-centre, double-blind, double-dummy placebo controlled, randomized Phase Ib Study to Evaluate the Safety and Immunogenicity of the Candidate Chikungunya vaccine ChAdOx1 Chik and the Zika vaccine ChAdOx1 Zika in Healthy Adults in Mexico, given as Standalone Vaccines or Co-administered
A Sequenced Strategy for Improving Outcomes in People with Knee Osteoarthritis Pain (SKOAP)
A Prospective, Single Center, Randomized, Intra-Patient Controlled Study Evaluating OsteoStrandTM Plus Demineralized Bone Fibers versus ViviGen® Lumbar Interbody Fusion
Favipiravir, lopinavir/ritonavir or combination therapy: a randomised, double blind, 2x2 factorial placebo- controlled trial of early antiviral therapy in COVID-19
A randomized controlled trial to compare the safety and efficacy of siroliMUs-eLuTIng biodegradable polymer ulTrA-thin stent (SUPRAFLEX™ Cruz) and everolimus- eLuting biodegradable polymer stent (SYNERGY™) in treatmENT for three-vessel coronary artery disease: Multivessel TALENT
Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy
The use of Benralizumab, an interleukin-5 receptor-α monoclonal antibody as treatment of acute exacerbations of airways disease
PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough
A Phase IIa, open label, single-site, 48 week randomised controlled trial evaluating the safety and efficacy of Exenatide once-weekly in the treatment of patients with Multiple System Atrophy
The Tight K Trial. Prevention of dysrhythmias on the cardiac intensive care unit - does maintenance of high-normal serum potassium levels matter?
Phase II, dose ranging, efficacy study of anti-thymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes (T1D)
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab
Trial of Ondansetron as a Parkinson’s HAllucinations Treatment
A Randomised Controlled Trial of plasma exchange with standard of care compared to standard of care alone in the treatment of severe COVID- 19 infection
Pharmacological management of seizures post traumatic brain injury – Duration
Pharmacological management of seizures post traumatic brain injury – Prophylaxis
British Heart Foundation Randomised Trial of Routine Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation
Clinical and cost-effectiveness of an in- home personalised health promotion intervention enabling independence in older people with mild frailty (‘HomeHealth’): A Randomised Controlled Trial
PROphylaxis for paTiEnts at risk of COVID-19 infecTion (PROTECT-V)
Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: Pilot of the intervention and Randomised Controlled Trial
Obeticholic Acid for the Amerlioration of Cognitive Symptoms trial -1
Obeticholic Acid for the Amerlioration of Cognitive Symptoms trial (OACS-2)
An Evaluation of the Safety and Effectiveness of the N-SWEAT Patch for the Treatment of Primary Axillary Hyperhidrosis or Excessive Axillary Sweating
Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy (UK-ROX).
To determine whether administration of almitrine bismesylate can ameliorate hypoxaemia in Covid-19 and augment effectiveness of supplementary oxygen therapy and respiratory support
Flow modulation using a surface modified device in the treatment of unruptured intracranial aneurysms using Dual versus mono-Antiplatelet therapy Randomized Trial
A parallel multi-centre randomised controlled trial to determine the clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carers
A pragmatic, multicentre, placebo-controlled, 3-arm, double-blinded, randomised controlled trial, incorporating an internal pilot, to determine the role of bronchodilators in preventing exacerbations of bronchiectasis
A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with a diagnosis of Autism
Metformin to prevent progression of sarcopenia and frailty in older people – a double blind, randomised controlled proof of concept trial
WOBE-SMART
A randomised, multicentre post-exposure prophylaxis (PEP) clinical trial evaluating RESP301, an inhaled therapy for treatment of lung infections, for prevention of onward transmission of viral infections including SARSCoV-2 to household members. (PREvent Viral Exposure aNd Transmission study: a SARS-CoV-2 PEP Study -PREVENT)
Comparative study of Advisor HD Grid versus Circular Mapping Catheters in assessment of pulmonary vein isolation following previous ablation for Atrial Fibrillation
Managing Unusual Sensory Experiences (MUSE): A feasibility trial of a targeted, psycho-education toolkit for distressing hallucinations, in people with a first episode of psychosis.
The effect of canagliflozin 300mg in subjects without diabetes after bariatric surgery on glucose homeostatis (the CONTROL study). A proof of concept, randomised, open label, two period cross over study
Dapagliflozin, Exercise Training and physicAL function: the DETA trial
Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: A Randomised Controlled Trial
A phase IIa, randomized, 2-arm parallel-group, placebo-controlled, double-blind, multi-centre trial to evaluate safety, tolerability, anti-inflammatory and cardio- protective effects after intravenous and oral administration of KAND567 in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention
SSO2 Therapy: AMIHOT III study
A prospective randomised controlled study of a directed psycho-educational tool to prevent psychological sequelae following Paediatric Intensive Care admission
Incorporating Supersaturated Oxygen in Shock
A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in unicondylar knee arthroplasty (UKA) procedures
Intravenous versus oral iron for iron deficiency anaemia in pregnant Nigerian women (IVON): an open label, randomized controlled trial
Bone Toxicity following Pelvic Radiotherapy: A prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecological cancers undergoing pelvic radiotherapy
Statins for Improving orGaN outcomE in Transplantation
A randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading (CHIP-BCIS3)
Prospective, Multi-center, Randomized, Controlled Study to Evaluate the Safety and Efficacy of the OR3O™ Dual Mobility System versus conventional single bearing design Total Hip System in Primary Total Hip Arthroplasty (THA) Procedures
A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in total knee arthroplasty (TKA) procedure
COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial
Pre-operative weight management to improve outcomes of cardiac surgery in adults with obesity (SLIM-CARD): a multicentre feasibility RCT
Alpha-1 Adrenergic Receptor Antagonism to Prevent Cytokine Storm Syndrome and Severe COVID-19: A Pragmatic Randomized Double-Blind Phase 2 Study Comparing the Efficacy of Doxazosin vs. Placebo for SARS-CoV-2 infection.
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis: a randomised placebo-controlled trial
Evaluating the clinical and cost effectiveness of using a permissive blood pressure target to guide titration of vasoactive drugs in critically ill children with hypotension. PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE
Positive Airway Pressure plus Mandibular Advancement Therapy
The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial.
The ASK trial: a feasibility trial of strategies to improve AccesS to Kidney transplantation
Erythropoietin and Darbepoetin in Neonatal Encephalopathy
Metformin Impact on Maternal and Infant Cardiometabolic Health
A phase III, randomised, double blinded, headto-head, single-site, cross-over trial of lamotrigine versus mexiletine for nondystrophic myotonias (MEND)
Randomised controlled trial of plasma cell depletion for severe Graves’ disease
Mycophenolate in limited cutaneous systemic sclerosis A randomised prospective open label pilot trial comparing mycophenolate mofetil with no immunosuppression in adults with limited cutaneous systemic sclerosis
A randomised controlled trial assessing the effectiveness and cost effectiveness of thrice weekly, extended, in-centre nocturnal haemodialysis versus standard care using a mixed methods approach
Healthcare Evaluation of Absolute Risk Testing: A multi-centre, single arm, pragmatic study in primary care setting
CCMR Two: A phase IIa, randomised, double-blind, placebo-controlled trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing- remitting multiple sclerosis already on disease-modifying therapy
A Multi-site, placebo controlled, double blind randomised clinical trial evaluating the effectiveness of sodium zirconium cyclosilicate versus placebo to enable safe optimisation of RASi therapy in patients with diabetic kidney disease
A Feasibility RCT of Early Vitrectomy and Intravitreal Antibiotics for post-operative exogenous eNdophthalmitis (EVIAN)
Live Well with Parkinson’s (as part of the program Personalised care for people with Parkinson’s Disease: PD-Care)
Online Parent Training for The Initial Management of ADHD Referrals: A two-arm parallel randomised controlled trial of a digital parenting intervention implemented on a treatment waitlist.
Randomised control trial of Tibial nerve stimulation in Parkinson’s disease
The Randomised Thoracoscopic Talc Poudrage + Indwelling Pleural Catheters versus Thoracoscopic Talc Poudrage only in Malignant Pleural Effusion Tria
The effect of dolutegravir on whole-body insulin sensitivity, lipid and endocrine profile in healthy volunteers
Sham controlled Randomized Control Trial evaluating the Safety, Acceptability and Efficacy of Autonomic neuromodulation using trans-cutaneous vagal sensory stimulation in uncontrolled hypertensive patients: a pilot study (SCRATCH –HTN)
Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury and metabolic acidosis Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care (MOSAICC)
A randomised trial of early detection of molecular relapse with circulating tumour DNA tracking and treatment with palbociclib plus fulvestrant versus standard endocrine therapy in patients with ER positive HER2 negative breast cancer
The holistic peripheral artery disease management trial
Feasibility of the NIDUS-professional home carer training intervention
Study to Reinforce Immunity (STRI) Phase 2 Clinical Trial
Effect of colon delivered vitamin C on gut microbiota and related health biomarkers in healthy older adults
Effect of colon delivered vitamin B2 and of a vitamin mix on gut microbiota and related health biomarkers in healthy older adults.
A Pilot Clinical Trial to Test the Acceptability and Feasibility of Oral Iron Supplementation in pregnant women
Amitriptyline for the prevention of post-herpetic neuralgia
Aspirin versus placebo in twin pregnancies for preeclampsia prevention: A multicenter, randomised, double-blind, placebo-controlled trial (ASPRE-T)
EarLy Exercise in blunt Chest wall Trauma: a mixed methods, multi-centre, parallel randomised controlled trial
Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital imaging? The Digital Imaging versus Ophthalmoscopy (DIvO) study
Assessing the Clinical and cost-Effectiveness of inpatient mental health Rehabilitation services provided by the NHS and independent sector (ACER)
Transformation of Dormant Spinal Networks to Mitigate Symptoms of Neurogenic Bladder (“SCONE Clinical Study”)
ENHANCE-D: Enhancing Dental Health Advice
PHOSP-COVID - Rehabilitation for lasting symptoms of COVID-19
The Foot-PAD trial: Effect of a footplate muscle stimulation program on walking capacity in people with Peripheral Artery Disease
A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children
BEARS - Both EARS training package (BEARS) to maximise hearing abilities in older children and teenagers with bilateral cochlear implants
A pragmatic, multi-centre, cluster-randomised trial of an integrated care pathway with a nested Phase III, open label, adaptive platform, randomised drug trial in individuals with Long COVID
Natalizumab for the treatment of people with inflammatory demyelination suggestive of multiple sclerosis, or definite multiple sclerosis, at first presentation.
Early Aortic Repair in patients Needing Endovascular/open Surgery for Type B Aortic Dissection (EARNEST): A randomised trial to assess the clinical and cost-effectiveness of thoracic endovascular aortic repair in the subacute phase after uncomplicated type B aortic dissection
PREMIUM - PeRioperative Encorafinib+binimetinib in BRAFV600 MUtant clinically detected AJCC stage III (B/C/D) or oligometastatic stage IV Melanoma
Multi-centre, randomised controlled trial of Vinehealth® digital health cancer solution for cancer patients commencing chemotherapy
Eye movement desensitisation and reprocessing for symptoms of post-traumatic stress disorder in adults with intellectual disabilities
Trial of Alginates in Throat Symptoms
Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications Including Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/Phaeochromocytoma, Medullary Thyroid Carcinoma, and Those Requiring Repeat Peptide Receptor Radionuclide Therapy
Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden
Implementation of Metformin theraPy to Ease Decline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD) Randomised Placebo-Controlled Trial
Posterior Laminectomy and FIXation for Degenerative Cervical Myelopathy
A double-blind randomised placebo-controlled feasibility study to assess the impact of octreotide infusion during liver transplantation on post-operative renal failure
OpenClinica
A double-blinded, randomised, placebo- controlled trial of semaglutide 2.4 mg in patients with poor weight-loss following bariatric surgery
Evaluation of safety and efficacy of a resorbable collagen implant in treatment of high grade partial thickness tears; a prospective, multicenter, randomized, control trial (IMPACT study)
Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED): A Randomised Controlled Trial
A multicentre randomised controlled trial of guided self-help versus treatment as usual for depression for autistic adults
Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistant depression in secondary mental health services
Early detection of bladder cancer in Yorkshire: Feasibility assessments for implementing a targeted study in populations with high disease specific mortality risk
Respiratory support with standard low flow oxygen therapy, frugal continuous positive airway pressure, or high-flow oxygen therapy in adults with acute hypoxemic respiratory failure in Uganda. Protocol for a randomized, open label, clinical trial.
An investigation of the efficacy of a novel sensory discrimination training device for the management of phantom limb pain: A randomised, single-blind, placebo-controlled trial.
Real world testing of an artificial intelligence- enabled app as an early intervention and support tool in the mental health referral care pathway
Non-Invasive Ventilation Outcomes score- directed Weaning (NIVOW) - Standard versus accelerated weaning from non- invasive ventilation (NIV) in chronic obstructive pulmonary disease directed by the NIV outcomes score: a randomised controlled trial
Erythropoietin Monotherapy in Neonatal Encephalopathy in Low and Middle-Income Countries
Randomised, double blind, placebo- controlled trial of L-serine in Hereditary Sensory Neuropathy type 1
Defatting of donor transplant livers during normothermic perfusion – a randomised clinical trial
A randomised, phase II, double blind, controlled mechanistic study of obinutuzumab versus rituximab in ANCA-associated vasculitis
A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
Optimising Primary Therapy in Primary Biliary Cholangitis
Intravenous ferric carboxymaltose versus oral ferrous sulphate for the treatment of moderate to severe postpartum anemia in Nigerian women (IVON-PP): an open label randomized controlled trial alongside an implementation study
A phase 2/3 randomised platform trial assessing the efficacy of aspirin, aspirin plus metformin, or resveratrol, for colorectal polyp prevention in patients undergoing surveillance in the Bowel Cancer Screening Programme
Nicotinamide in Glaucoma (NAMinG): A randomized, placebo-controlled, multi-centre, Phase III trial
The Threshold for Platelets (T4P) Study: A prospective randomised trial to define the platelet count below which critically ill patients should receive a platelet transfusion prior to an invasive procedure.
Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial
MUSE ARMS Feasibility RCT: A feasibility trial employing a prospective randomised, open- label, observer blinded, endpoint design assessing a targeted, computer/web based guided self-help psycho-education toolkit for distressing hallucinations (MUSE) +treatment as usual (TAU) compared to a time matched TAU, offered by a multi-disciplinary team which includes emotional support, psychoeducation and stress management, aiming to reduce distress from hallucinations and improve functioning, , in people with an At Risk Mental State (ARMS) for psychosis in UK secondary care mental health services.
Phoenix VR Self-Confidence Study
A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children
A single-center, double-blind, randomized, placebo-controlled Phase 1 study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses of IDOR- 1117-2520 in healthy subjects
Digital Diabetes Remission Trial
Comparison of clinical effectiveness and cost-effectiveness of a remote monitoring programme versus usual care in Interstitial Lung Disease
Fibre Supplements For Pre-diabetes
UPDATE (Crossover diet trial Diet A then Diet B or Diet B then Diet A)
Targeted drug intervention in men at risk of progression on active surveillance for early prostate cancer: A randomised trial – Therapeutics in Active Prostate cancer Surveillance (TAPS02)
First trial of enterprise subscription
A Multi-Centre Randomised Controlled Trial of the Clinical and Cost-Effectiveness of Pre- Hospital Whole Blood Administration versus Standard Care for Traumatic Haemorrhage
The clinical impact of customised Positive Airway Pressure (PAP) therapy interfaces vs usual care in the treatment of patients with sleep disordered breathing
Aripiprazole/sertraline combination: clinical and cost-effectiveness in comparison with quetiapine for the treatment of bipolar depression.
The effect of interrupting sitting with regular active breaks on glycaemia and daily insulin dose in sedentary people with type 1 diabetes
An Evaluation of Remote Care (Questionnaire+Hybrid) in Patients Who Are Post-lung Transplant
A randomised controlled trial to evaluate effectiveness and cost-effectiveness of intermittent colonic exoperistalsis treatment with MOWOOT medical device in adults with chronic constipation using trans-anal irrigation.
Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multi-morbidity) PERFORM: Feasibility study
Assessment of the impact of a TeleHealth Program for the control of modifiable risk factors in people at risk of Diabetes-related Foot Disease
A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI vaccines in African children
Parenting course for parents of children with fetal alcohol spectrum disorders (FASD) versus waitlist: a randomised controlled feasibility study of the SPECIFIC (Salford Parents and carers’ Education Course for Improvements in Fasd outcomes In Children) Programme
Optimising azithromycin prevention treatment in COPD to reduce exacerbations (OPACE): A double blind adaptive design pragmatic phase IV randomised controlled trial
A Prospective, Single-blind, Multi-Centre, Randomised Controlled Study to Evaluate the Clinical and Patient Reported Outcomes Following Unicompartmental Knee Arthroplasty with a Robotic Assisted Technique
Neuromuscular Electrical Stimulation For The Treatment Of Diabetic Neuropathy: A Multi-centre, Double-blind, Pilot, Randomised, Sham-controlled Trial (NMES-DN)
A randomized, double-blind, placebo-controlled, 2 period, crossover study to evaluate the efficacy and safety of ATX01 (topical amitriptyline hydrochloride 15% w/w) in adult patients with pain due to erythromelalgia (EM)
The Supervised home-based exercise program for Peripheral artery disease trial.
Child Improvisational Music Therapy Effectiveness Randomised Controlled Trial for autistic children aged 7 – 11 [Autism-CHIME]
INterFeron gamma to prevent INfection in InTensive care units
Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD): A Phase III multi-centre randomised placebo-controlled trial
A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis
Fisetin Dosing Study
Effect of BH-HF3.0 on Vasomotor Symptoms (VMS) in Menopausal Women: A De-Centralized, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Prepare for Kidney Care: a randomised controlled trial of preparing for responsive management versus preparing for renal dialysis in advanced kidney disease
A Randomised-Control Trial of Fluorescence Guided Sarcoma Surgery Versus the Standard of Care
Digital thErapy For Improved tiNnitus carE Study
Equally Safe at School
Personalised treatment packages for adults with learning disabilities who display aggression in community settings: a cluster randomised controlled trial Cluster randomised trial
Empowering Better End of Life Care
Brief Intervention with Cyclophosphamide in patients with Colorectal Cancer who completed treatment
Impact of feedback from Real-time, electronic symptom monitoring on post- discharge recOvery after Surgery for oEsophago-gastric cancer: a multi-centre randomised controlled trial
PrEgabalin for Treatment Resistant generalised Anxiety disorder
A randomised controlled trial assessing the clinical and cost- effectiveness of Endovascular vs. Open revascularisation in severe oCClusive aorto-iliac disease. The EVOCC Trial
MBCT-vision to treat Visual Snow Syndrome: a Randomised Controlled Trial
The impact of a holistic multifactorial management intervention in adults with early-onset type 2 diabetes (aged 16 to 45 years): The M3 randomised controlled trial. Might involved second randomisation as a SWAT
Endoscopic Lavage after Intraventricular Haemorrhage in Neonates in the UK: A national randomised controlled trial on the efficacy of neuro-endoscopic lavage
A randomized, double-blind, placebo-controlled, parallel study, to assess the effect of bifidobacterial supplementation on bowel movements
A Randomized Controlled Trial Evaluating the Safety and Effectiveness of the AI- Driven Signos System for Personalized Weight Management in Overweight and Obese Adults
A randomised controlled trial of regular MRI scans compared to standard care in patients with prostate cancer managed using active surveillance
A randomised, double-blind, placebo-controlled trial examining the safety and efficacy of deferiprone in patients with neuroferritinopathy
Breathing Assistance in CHildren with bronchiolitis
There are 3 SepTIC trials (imperial16, imperial17, imperial18)
Managing chronic Myalgia Temporomandibular Disorder (M-TMD): a pragmatic phase III definitive three-arm parallel-group, co-primary outcome, individually randomised open-label controlled superiority trial comparing the clinical- and cost-effectiveness and safety of Botulinum toxin type A, Lidocaine, and Amitriptyline/Gabapentin, with internal pilot and cost-effectiveness analysis (MiTiGate)
PROthrombin complex concentrate versus fresh frozen Plasma for bleeding in adults undergoing HEart SurgerY (PROPHESY- 2 trial): a phase III, randomised control trial
Thromboprophylaxis in Lower Limb Immobilisation
Hip Implant Prosthesis Programme for the Younger total hip replacement patient (HIPPY)
A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
Home initiation and monitoring of non- invasive ventilation versus hospital-based care in people with Motor Neurone Disease: A Randomised Control Trial (RCT) and Qualitative Study
The effectiveness and cost effectiveness of COenzyme Q10 in heaRt fAiLure with reduced ejection fraction (CORAL): a pragmatic, patient-centred, data-enabled trial in primary care
A Randomized, Participant and Investigator Blinded, Placebo-Controlled Study to Evaluate the ability of intrathecally (IT) administered NIO752 to lower Cerebrospinal Fluid (CSF) Total tau synthesis in participants with Alzheimer’s Disease (AD) measured by stable isotope labelling kinetics (SILK)
TrAnexamic acid to pRevent anastomotic leak after rectal cancer surGEry: a feasibility sTudy
European blood Pressure Intensive Control after Stroke – Pilot trial
A randomised phase II study of Zimberelimab anti-PD1 immunOtherapy +/- Domvanalimab anti-TIGIT immunotherapy in resectable mismatch repair deficient gastric and gastro- oesophageal junctional AdenoCarcinoma
PravastatIn tO preveNt prEtErm biRth (PIONEER): a parallel group randomised placebo-controlled trial
Phase III Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy of the Addition of Crenolanib to Salvage Chemotherapy Versus Salvage Chemotherapy Alone in Subjects less than 75 Years of Age with Relapsed/Refractory FLT3 Mutated Acute Myeloid Leukemia
A double-blind, randomized, placebo- controlled, two-part, Phase 1 trial to assess the safety, tolerability, and immunogenicity of up to 3 ascending dose levels of IDOR-1134-2831 vaccine in healthy participants < 50 and ≥ 50 years of age PART A
A double-blind, randomized, placebo- controlled, two-part, Phase 1 trial to assess the safety, tolerability, and immunogenicity of up to 3 ascending dose levels of IDOR-1134-2831 vaccine in healthy participants < 50 and ≥ 50 years of age PART B
A multi-Site randomised trial of surgical versus percutaneous revascularisation of ischaemic left ventricular dysfunction in the United Kingdom, with embedded internal pilot and health economic analysis (STICH3-BCIS-4)
Investigating and optimising physical function with weight loss: a multi-arm open label adaptive platform trial
Multicentric randomized non-inferiority study examining the effect of the digital medical device Poppins Clinical for cognitive and musical training in addition to reduced conventional standard of care on the reading and writing skills of pediatric participants with a specific learning disability with reading and/or written expression deficit compared with a control group receiving conventional standard of care (POPPINS-02).
Exercise Prescription Improved through Co-design for people with chronic non-specific Neck pain (EPIC-Neck): A randomised feasibility study with process evaluation
Should we use post-operative antibiotics to prevent surgical site infections (SSIs) following surgery for patients with mandible fractures? The MANTRA trial – a Phase III, non-inferiority, non-blinded, pragmatic Randomised Controlled Trial
Assessment of safety, immunogenicity and efficacy of R21/ Matrix-M malaria vaccine in healthy women of childbearing potential in Mali
Cooling in Mild Encephalopathy versus Targeted normothermia (COMET) trial
ACESO trial: Upadacitinib Co-therapy with Corticosteroids in Early Acute Severe Ulcerative Colitis (A Phase III randomised placebo controlled double blinded trial)
Randomised controlled trial of the safety and efficacy of PHOE-01 in ME/CFS with digital monitoring
Continuous glucose monitoring for improving clinical outcome and quality of life in patients with diabetes and cancer
Severe Malaria A Research and Trials consortium - Multisite Adaptive Platform trial
Antidepressants to prevent relapse in depression in older people (ANTLER 75+ Trial) – a double blind randomised controlled trial to evaluate the effectiveness and cost-effectiveness of continuing antidepressants
A pilot study to investigate the relative effectiveness and safety of chemical wound debridement and curettage in the treatment of venous and mixed aetiology leg ulcers
Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)-The PERFORM trial
Safety And Efficacy of Remotely Supervised Home-Based tDCS Treatment Of Major Depressive Disorder (REACH- tDCS)
An artificial-intelligence-powered intervention to aid the informed consent process for cataract surgery for English and Bengali speaking patient population groups: A mixed-methods randomised control trial
Preventing kidney injury using carbon dioxide as contrast medium in patients with Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) having arterial intervention
Investigating and optimising physical function with weight loss: a multi-arm open label adaptive platform trial
nvestigating and optimising physical function with weight loss: a multi-arm open label adaptive platform trial
Exacerbation Prevention in chronic obstructive pulmonary disease (COPD) – obstructive sleep apnoea (OSA) overlap syndrome: The clinical and health economic impact of treating patients with COPD-OSA overlap syndrome and a high risk of future exacerbations with positive airway pressure therapy (PAP) a multicentre randomised controlled trial
Randomised Evaluation of Surgical teChniques for patients Undergoing Emergency Cranial Decompression for TBI patients (RESCUE-CD TBI)
TailorEd iNtervention for brain HeAlth aNd Cognitive Enrichment (ENHANCE) for underserved people at higher risk of dementia in the UK
VOYAGER: A decentralised open label trial to eValuate the efficacy Of the VoY program in A patient population using GLP/GIP-1RA thERapy.
Timing Of venous thromboembolism Prophylaxis for adult patients with Traumatic Brain Injury (TOP-TBI): a pragmatic, randomised trial
Determining the feasibility of randomising children and young people to invasive and non-invasive urine sampling techniques (FROG) A pragmatic multi centred randomised controlled feasibility trial and a mixed methods feasibility perspectives study
Effectiveness of Frieda Menova in menopausal and climacteric states
A Randomised Controlled Trial of Oviva Direkt for Improvement of Glycaemic Control in Patients Living with Type 2 Diabetes Mellitus (T2DM)
The OPTIMAL feasibility trial: OPTimising IMmunosuppression for older Adult kidney transpLant recipients
Clinical- and cost-effectiveness, safety, and acceptability of COMBined phacovitrectomy, versus sequentiAl viTrectomy and cataract surgery, for the management of rhegmatogenous retinal detachment: A Randomised Equivalence Clinical Trial
A Probiotic Strain for Metabolic Health and Well Being: A randomised placebo-controlled trial
The use of neuromuscular electrical STIMulation as a treatment for sarcopenia in people on HaemoDialysis (STIM-HD)
Prognostic model for predicting outcome after traumatic brain injury
A prognostic model that may be used as an aid to estimate the risk of incident locomotor disability within 7 years. Developed from data collected in the British Women's Heart and Health Study.
A prognostic model that may be used as an aid to estimate the risk of coronary and cardiovascular death in patients with suspected angina.